C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category ° Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. X SHEN LEI ET AL:"Enhancement of human 1,2,4, protein C function by site-directed 7-10,13, mutagenesis of the gamma-carboxyglutamic 43,44, aciddomain."46, JOURNAL OF BIOLOGICAL CHEMISTRY, 51-58,75 vol. 273, no. 47, 20 November 1998 (1998-11-20), pages 31086-31091,XP002149742 ISSN:0021-9258 Y the whole document 2,3 Y MCDONALD J F ET AL :"Comparison of 2,3 naturally occurring vitamin K-dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site" BIOCHEMISTRY, US, AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 36, no. 17, 29 April 1997 (1997-04-29), pages 5120-5127,XP002092840 ISSN:0006-2960 the whole document 2 Box I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet) This International Search Report has not been established in respect of certain claims under Article 17 (2) (a) for the following reasons: 1. X Claims Nos. : because they relate to subject matter not required to be searched by this Authority, namely: Although claims 53 and 54 are directed to a method of treatment of the human/animal body, the search has been carried out and based on the alleged effects of the compound/composition. ry1 2. Claims Nos. : because they relate to parts of the International Application that do not comply with the prescribed requirements to such an extent that no meaningful International Search can be carried out, specifically: 3. Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4 (a). Box 11 Observations where unity of invention is lacking (Continuation of item 2 of first sheet) This International Searching Authority found multiple inventions in this international application, as follows: see additional sheet 1. As all required additional search fees were timely paid by the applicant, this International Search Report covers all searchable claims. 2. as ait searchable claims could be searched without effort justifying an additional fee, this Authority did not invite payment of any additional fee. 3. As only some of the required additional search fees were timely paid by the applicant, this International Search Report covers only those claims for which fees were paid, specifically claims Nos.: 4. No required additional search fees were timely paid by the applicant. Consequently, this International Search Report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: Claims 7-15 compeletely, 1-6,31,39-43,51-58,75 partially. Remark on Protest ! The additional search fees were accompanied by the applicant's protest. No protest accompanied the payment of additional search fees. u FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 This International Searching Authority found multiple (groups of) inventions in this international application, as follows : 1. Claims: 7-15 44-47 completely, 1-6 31 39-43 51-58 75 partially Protein C with modified GLA domain, its use and nucleic acids encoding it 2. Claims: 16-20 32 33 48 49 60-62 64 65 67 68 completely 1-6 31 39-43 51-59 63 66 70-75 partially Factor VII with modified GLA domain, its use and nucleic acids encoding it 3. Claims: 21-26 completely 1-6 31 39 40 43 50-58 75 partially Protein S with modified GLA domain, its use and nucleic acids encoding it 4. Claims: 27-30 69 completely 1-6 31 39 43 50-59 63 66 70-75 partially Factor IX with modified GLA domain, its use and nucleic acids encoding it 5. Claims : 34-36 1-6 31 39 40 43 51-53 55-58 75 partially Factor X with modified GLA domain, its use and nucleic acids encoding it 6. Claims: 37 38 completely 1-6 31 39 43 51-53 55-58 75 partially Protein Z with modified GLA domain, its use and nucleic acids encoding it Patent document Publication Patent family Publication cited in search report date member (s) date WO 9920767 A 29-04-1999 US 6017882 A 25-01-2000 AU 2702499 A 10-05-1999 BR 9814611 A 03-10-2000 NO 20002025 A 19-06-2000 ZA 9809597 A 23-04-1999