Title:
MODULATION OF NKG2D
Document Type and Number:
WIPO Patent Application WO2005097160
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells and/or NK cells, by modulating NKG2D.
More Like This:
| JPS5344560 | POLYPEPTIDE DERIVATIVE AND ITS PREPARATION |
| WO/2002/002630 | HCN POLYPEPTIDES AND POLYNUCLEOTIDES AND THEIR USE IN THERAPY |
| WO/2001/081576 | NOVEL G PROTEIN-COUPLED RECEPTOR CON-218 |
Inventors:
LANIER LEWIS L (US)
OGASAWARA KOETSU (US)
BLUESTONE JEFFREY A (US)
OGASAWARA KOETSU (US)
BLUESTONE JEFFREY A (US)
Application Number:
PCT/US2005/011487
Publication Date:
March 16, 2006
Filing Date:
April 05, 2005
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
LANIER LEWIS L (US)
OGASAWARA KOETSU (US)
BLUESTONE JEFFREY A (US)
LANIER LEWIS L (US)
OGASAWARA KOETSU (US)
BLUESTONE JEFFREY A (US)
International Classes:
A61K38/00; C07K16/28; (IPC1-7): A61K38/17; A61K39/395; A61P37/02
Other References:
OGASAWARA KOUETSU ET AL: "Impairment of NK cell function by NKG2D modulation in NOD mice.", IMMUNITY, vol. 18, no. 1, January 2003 (2003-01-01), pages 41 - 51, XP002359220, ISSN: 1074-7613
LODOEN MELISSA ET AL: "NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 197, no. 10, 19 May 2003 (2003-05-19), pages 1245 - 1253, XP002359221, ISSN: 0022-1007
OGASAWARA KOUETSU ET AL: "NKG2D blockade prevents autoimmune diabetes in NOD mice", IMMUNITY, vol. 20, no. 6, June 2004 (2004-06-01), pages 757 - 767, XP002359222, ISSN: 1074-7613
LODOEN MELISSA ET AL: "NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 197, no. 10, 19 May 2003 (2003-05-19), pages 1245 - 1253, XP002359221, ISSN: 0022-1007
OGASAWARA KOUETSU ET AL: "NKG2D blockade prevents autoimmune diabetes in NOD mice", IMMUNITY, vol. 20, no. 6, June 2004 (2004-06-01), pages 757 - 767, XP002359222, ISSN: 1074-7613
Download PDF:
Previous Patent: REMEDY FOR NEURODEGENERATIVE DISEASES
Next Patent: GPE AND G-2MEPE, CAFFEINE AND ALKANOL FOR TREATMENT OF CNS INJURY
Next Patent: GPE AND G-2MEPE, CAFFEINE AND ALKANOL FOR TREATMENT OF CNS INJURY