REMEDY FOR NEURODEGENERATIVE DISEASES

Title:

REMEDY FOR NEURODEGENERATIVE DISEASES

Document Type and Number:

WIPO Patent Application WO/2005/097156

Kind Code:

A1

Abstract:

A medicinal composition for treating and/or preventing neurodegenerative diseases which contains, as the active ingredient, a polypeptide represented by one of the following (a) to (c): (a) a polypeptide containing an amino acid sequence Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO:1); (b) a polypeptide containing an amino acid sequence derived from the amino acid sequence Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO:1) by deletion, substitution, insertion and/or addition of one to several amino acids and having an activity of inhibiting nerve cell death relating to neurodegenerative diseases; and (c) a polypeptide which is a modification of a polypeptide of (a) or (b); or a pharmaceutically acceptable salt thereof.

Inventors:

CHIBA TOMOHIRO (JP)
KITA YOSHIKO (JP)
MATSUOKA MASAAKI (JP)
TERASHITA KENZO (JP)
AISO SADAKAZU (JP)
NISHIMOTO IKUO DI

Application Number:

PCT/JP2005/007286

Publication Date:

October 20, 2005

Filing Date:

April 08, 2005

Export Citation:

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Assignee:

CHIBA TOMOHIRO (JP)
KITA YOSHIKO (JP)
MATSUOKA MASAAKI (JP)
TERASHITA KENZO (JP)
AISO SADAKAZU (JP)
NISHIMOTO TOMO HF (JP)

International Classes:

A61K38/00; A61K38/08; A61K38/16; A61P25/02; A61P25/28; C07K7/06; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; (IPC1-7): A61K38/00; A61P25/28; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02

Domestic Patent References:

WO2003097687A2	2003-11-27
WO2001021787A1	2001-03-29
WO2001012654A2	2001-02-22
WO2000053217A2	2000-09-14

Foreign References:

JP2003535105A	2003-11-25
JP2001522228A	2001-11-13

Other References: