MONO- AND DIACYLGLYCEROL ACYLTRANSFERASES AND METHODS OF USE THEREOF

WIPO Patent Application WO2004042014

A3

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2a, MGAT1, or MGAT2 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2a, MGAT1, or MGAT2 activity; DGAT2a, MGAT1, or MGAT2 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.

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CASES SYLVAINE (US)
STONE SCOT J (US)
ZHOU PING (US)
FARESE ROBERT V (US)
YEN CHI-LIANG ERIC (US)

PCT/US2003/034598

March 02, 2006

October 29, 2003

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DAVID GLADSTONE INST (US)

C12N9/10; A61K38/00; (IPC1-7): C07H21/04; A61K38/43; C07K1/00; C12N1/20; C12N9/00; C12N15/00; C12Q1/68

WO2000005367A2

2000-02-03

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