Title:
MONO HALOGEN OR METHYL-SUBSTITUTED 5-HT2B ANTAGONISTS WITH INCREASED ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/063999
Kind Code:
A1
Abstract:
Disclose herein are mono halogen or methyl-substituted 5-HT 2B antagonist compounds, which have been found with increased binding activity to 5-HT 2B receptor due to the substitution of halogen or methyl, and the method of using the compounds of treating or preventing a disorder mediated by 5-HT 2B.
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Inventors:
HUANG NIU (CN)
ZHOU YU (CN)
WANG YUANXUN (CN)
ZHOU YU (CN)
WANG YUANXUN (CN)
Application Number:
PCT/CN2019/109311
Publication Date:
April 02, 2020
Filing Date:
September 30, 2019
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07C211/28; A61K31/335; A61K31/395; A61K31/44; A61P25/18; A61P25/20; A61P25/22; A61P25/24; C07C211/29; C07C211/31; C07C211/32; C07D313/10; C07D337/10; C07D409/04
Foreign References:
| CA785308A | 1968-05-14 | |||
| EP0409406A2 | 1991-01-23 | |||
| CA1085403A | 1980-09-09 | |||
| US3464983A | 1969-09-02 |
Other References:
WINTHROP, STANLEY O . ET AL.: "New Psychotropic Agents. Derivatives of Dibenzo®, d]-l, 4- cy cloheptadiene", JOURNAL OF ORGANIC CHEMISTRY, vol. 27, 31 January 1962 (1962-01-31), pages 230 ; 234
ENGELHARDT, EDWARD L. ET AL.: "Structure-activity relations in the cyproheptadine series", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, 30 November 1965 (1965-11-30), pages 831, XP000612118
HIRANO, TOMOYA ET AL.: "Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine", CHEMMEDCHEM, vol. 13, no. 15, 6 July 2018 (2018-07-06), pages 1530 - 1533 ; 1539
BASTIAN, J. M. ET AL.: "Synthetic drugs. XV. 4H-Benzo[4, 5]cyclohepta[1, 2-b]thiophenes", HELVETICA CHIMICA ACTA, vol. 49, no. 1, 30 December 1965 (1965-12-30), pages 221
ENGELHARDT, EDWARD L. ET AL.: "Structure-activity relations in the cyproheptadine series", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, 30 November 1965 (1965-11-30), pages 831, XP000612118
HIRANO, TOMOYA ET AL.: "Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine", CHEMMEDCHEM, vol. 13, no. 15, 6 July 2018 (2018-07-06), pages 1530 - 1533 ; 1539
BASTIAN, J. M. ET AL.: "Synthetic drugs. XV. 4H-Benzo[4, 5]cyclohepta[1, 2-b]thiophenes", HELVETICA CHIMICA ACTA, vol. 49, no. 1, 30 December 1965 (1965-12-30), pages 221
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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