Title:
MONO-TIN ORGANIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/141457
Kind Code:
A1
Abstract:
The present application provides a mono-tin organic compound which is used for synthesizing sucrose-6-carboxylate. The compound is a compound represented by formula (1) below. R1, R2 and R3 each independently represent C1-C8 linear or branched saturated alkyl, C2-C8 linear or branched unsaturated alkyl, C3-C8 substituted or unsubstituted saturated cycloalkyl, C3-C8 substituted or unsubstituted unsaturated cycloalkyl or C6-C12 aryl or substituted aryl, and R4 represents C1-C6 linear or branched saturated alkyl or C6-C12 aryl or substituted aryl. The mono-tin organic compound of the present application enables accurate metering and feeding in the process of synthesizing sucrose-6-carboxylate, improves the catalyst recovery rate and reduces the occurrence of a subsequent chlorination side reaction at the same time, and has faster reaction, lower energy consumption and a higher yield per unit volume.
Inventors:
TAO CHANGWEN (CN)
ZHAO JINGANG (CN)
ZHENG XUELIAN (CN)
LUO JIALONG (CN)
CHEN CHAOHUI (CN)
ZHAO JINGANG (CN)
ZHENG XUELIAN (CN)
LUO JIALONG (CN)
CHEN CHAOHUI (CN)
Application Number:
PCT/CN2020/142289
Publication Date:
July 07, 2022
Filing Date:
December 31, 2020
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07F7/22; B01J31/22; C07H1/00; C07H13/06
Foreign References:
| GB797073A | 1958-06-25 | |||
| GB1593589A | 1981-07-22 | |||
| CN102453237A | 2012-05-16 | |||
| US3361775A | 1968-01-02 |
Other References:
WUTHIER URS, ET AL.: "Anion Selectivities of Triorganyltin Acetates and Halides in Solvent Polymeric Membranes", HELVETICA CHIMICA ACTA, vol. 69, no. 6, 10 September 1986 (1986-09-10), pages 1435 - 1441, XP055948449, DOI: 10.1002/hlca.19860690616
ZIMMER HANS, ET AL.: "Sterically hindered Group IVa organometallics. VI. Preparation and Properties of Neophyltins and Related Compounds", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 31, no. 11, 1 November 1966 (1966-11-01), pages 3857 - 3860, XP055948453, ISSN: 0022-3263, DOI: 10.1021/jo01349a515
SASIN GEORGE S: "REACTIONS OF BIS-(TRIETHYLTIN) OXIDE WITH ACIDS. TRIETHYLTIN MERCAPTIDES", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 18, no. 9, 1 September 1953 (1953-09-01), pages 1142 - 1145, XP055948454, ISSN: 0022-3263, DOI: 10.1021/jo50015a012
CHIH HWA, PENFOLD B R: "Crystal and molecular structures of two polymeric organotin carboxylates, CsHI~O2Sn and CsHgF302Sn", JOURNAL OF CRYSTAL AND MOLECULAR STRUCTURE, SPRINGER,, US, vol. 3, 30 September 1973 (1973-09-30), US , pages 285 - 297, XP055948464, ISSN: 0308-4086
G. A. RAZUVAEV ET AL.: "[Reaction of acyl peroxides with organic derivatives of lead, tin and silicon]", DOKLADY AKADEMII NAUK SSSR, vol. 137, no. 3, 31 December 1961 (1961-12-31), RU , pages 618 - 621, XP009538017, ISSN: 0002-3264
VAN DER KERK G.J.M., J.G.A. LUIJTEN: "Investigations on organotin compounds. V The preparation and antifungal properties of unsymmetrical tri-n-alkyltin acetates", JOURNAL OF APPLIED CHEMISTRY, WILEY, US, vol. 6, no. 2, 1 February 1956 (1956-02-01), US , pages 56 - 60, XP055948467, ISSN: 0021-8871, DOI: 10.1002/jctb.5010060202
RUDOLPH WILLEM ET AL.: "Synthesis, characterization and in vitro antitumor activity of triphenyl and tri-n-butyltin benzoates, phenylacetates and cinnamates", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 531, no. 1-2, 15 March 1997 (1997-03-15), XP004075035, ISSN: 0022-328X, DOI: 10.1016/S0022-328X(96)06686-7
TOMOYA OGAWA ET AL.: "A stereocontrolled approach to the synthesis of glycosyl esters. Partial synthesis of stevioside from steviobioside", CARBOHYDRATE RESEARCH, vol. 60, no. 1, 31 January 1978 (1978-01-31), XP026618472, ISSN: 0008-6215, DOI: 10.1016/S0008-6215(00)83484-9
XIE QINGLAN, ET AL.: "The Structure and Biological Activity of Tributyltin Carboxylates", ACTA CHIMICA SINICA, ZHONGGUO KEXUEYUAN SHANGHAI YOUJI HUAXUE YANJIUSUO, CN, vol. 49, no. 7, 30 July 1991 (1991-07-30), CN , pages 723 - 728, XP055948470, ISSN: 0567-7351
See also references of EP 4206208A4
ZIMMER HANS, ET AL.: "Sterically hindered Group IVa organometallics. VI. Preparation and Properties of Neophyltins and Related Compounds", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 31, no. 11, 1 November 1966 (1966-11-01), pages 3857 - 3860, XP055948453, ISSN: 0022-3263, DOI: 10.1021/jo01349a515
SASIN GEORGE S: "REACTIONS OF BIS-(TRIETHYLTIN) OXIDE WITH ACIDS. TRIETHYLTIN MERCAPTIDES", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 18, no. 9, 1 September 1953 (1953-09-01), pages 1142 - 1145, XP055948454, ISSN: 0022-3263, DOI: 10.1021/jo50015a012
CHIH HWA, PENFOLD B R: "Crystal and molecular structures of two polymeric organotin carboxylates, CsHI~O2Sn and CsHgF302Sn", JOURNAL OF CRYSTAL AND MOLECULAR STRUCTURE, SPRINGER,, US, vol. 3, 30 September 1973 (1973-09-30), US , pages 285 - 297, XP055948464, ISSN: 0308-4086
G. A. RAZUVAEV ET AL.: "[Reaction of acyl peroxides with organic derivatives of lead, tin and silicon]", DOKLADY AKADEMII NAUK SSSR, vol. 137, no. 3, 31 December 1961 (1961-12-31), RU , pages 618 - 621, XP009538017, ISSN: 0002-3264
VAN DER KERK G.J.M., J.G.A. LUIJTEN: "Investigations on organotin compounds. V The preparation and antifungal properties of unsymmetrical tri-n-alkyltin acetates", JOURNAL OF APPLIED CHEMISTRY, WILEY, US, vol. 6, no. 2, 1 February 1956 (1956-02-01), US , pages 56 - 60, XP055948467, ISSN: 0021-8871, DOI: 10.1002/jctb.5010060202
RUDOLPH WILLEM ET AL.: "Synthesis, characterization and in vitro antitumor activity of triphenyl and tri-n-butyltin benzoates, phenylacetates and cinnamates", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 531, no. 1-2, 15 March 1997 (1997-03-15), XP004075035, ISSN: 0022-328X, DOI: 10.1016/S0022-328X(96)06686-7
TOMOYA OGAWA ET AL.: "A stereocontrolled approach to the synthesis of glycosyl esters. Partial synthesis of stevioside from steviobioside", CARBOHYDRATE RESEARCH, vol. 60, no. 1, 31 January 1978 (1978-01-31), XP026618472, ISSN: 0008-6215, DOI: 10.1016/S0008-6215(00)83484-9
XIE QINGLAN, ET AL.: "The Structure and Biological Activity of Tributyltin Carboxylates", ACTA CHIMICA SINICA, ZHONGGUO KEXUEYUAN SHANGHAI YOUJI HUAXUE YANJIUSUO, CN, vol. 49, no. 7, 30 July 1991 (1991-07-30), CN , pages 723 - 728, XP055948470, ISSN: 0567-7351
See also references of EP 4206208A4
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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