Title:
MONOCLONAL ANTIBODY FOR DETECTING ANTI-CD19 CAR EXPRESSION LEVEL AND USE THEREOF IN ACTIVATING CD19 CAR-T CELL
Document Type and Number:
WIPO Patent Application WO/2024/061021
Kind Code:
A1
Abstract:
Provided are an anti-CD19 CAR molecular antibody and a method for using the antibody. The antibody can specifically bind to CD19 CAR-FMC63, can specifically, sensitively and accurately detect a CD19 CAR positive cell, can be used for detecting the activation function of a CAR-T cell, and meets the requirements of CAR-T medicament production quality control, clinical treatment monitoring and auxiliary diagnosis.
Inventors:
WANG HONGFEI (CN)
HU YANG (CN)
DA LIANG (CN)
WEI GUOWEI (CN)
ZHANG YARU (CN)
TANG LANXIANG (CN)
BAO XIN (CN)
HU YANG (CN)
DA LIANG (CN)
WEI GUOWEI (CN)
ZHANG YARU (CN)
TANG LANXIANG (CN)
BAO XIN (CN)
Application Number:
PCT/CN2023/117611
Publication Date:
March 28, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
BIOSWAN LABORATORIES CO LTD (CN)
International Classes:
C07K16/28; G01N33/569
Domestic Patent References:
| WO2016112855A1 | 2016-07-21 |
Foreign References:
| CN111349161A | 2020-06-30 | |||
| CN110894238A | 2020-03-20 | |||
| CN108508200A | 2018-09-07 | |||
| CN105837689A | 2016-08-10 |
Other References:
PARK, J. H. ET AL.: "CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date", BLOOD, vol. 127, no. 26, 20 May 2016 (2016-05-20), pages 3312 - 3320, XP055449358, DOI: 10.1182/blood-2016-02-629063
Attorney, Agent or Firm:
NANJING CIPIC INTELLECTUAL PROPERTY FIRM (GENERAL PARTNERSHIP) et al. (CN)
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