Title:
MRNA CAP ANALOG AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/191342
Kind Code:
A1
Abstract:
One aspect relates to a compound of chemical formula 1, a cap analog comprising same, mRNA 5'-capped with the cap analog, a method for preparing mRNA by using the cap analog, a use for using the cap analog for preparing mRNA, and a pharmaceutical composition for expressing a desired peptide or protein comprising mRNA 5'-capped with the cap analog.
Inventors:
KIM NA RI (KR)
CHOI BO SUNG (KR)
NOH JIN MI (KR)
MIN SU HYEON (KR)
JUNG YONG GYU (KR)
CHOI BO SUNG (KR)
NOH JIN MI (KR)
MIN SU HYEON (KR)
JUNG YONG GYU (KR)
Application Number:
PCT/KR2023/003327
Publication Date:
October 05, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
HANMI FINE CHEMICAL CO LTD (KR)
International Classes:
C07H21/04; A61K31/7105; C07H1/00; C07H21/02; C12N15/11
Foreign References:
| US20140147454A1 | 2014-05-29 | |||
| KR20200143391A | 2020-12-23 |
Other References:
MALWINA STRENKOWSKA, RENATA GRZELA, MACIEJ MAJEWSKI, KATARZYNA WNEK, JOANNA KOWALSKA, MACIEJ LUKASZEWICZ, JOANNA ZUBEREK, EDWARD D: "Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, GB , pages gkw896, XP055605255, ISSN: 0305-1048, DOI: 10.1093/nar/gkw896
MALWINA STRENKOWSKA, KOWALSKA JOANNA, LUKASZEWICZ MACIEJ, ZUBEREK JOANNA, SU WEI, RHOADS ROBERT E., DARZYNKIEWICZ EDWARD, JEMIELIT: "Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 34, no. 5, 1 January 2010 (2010-01-01), GB , pages 993, XP055553163, ISSN: 1144-0546, DOI: 10.1039/b9nj00644c
M. ISHIKAWA, R. MURAI, H. HAGIWARA, T. HOSHINO, K. SUYAMA: "Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation", NUCLEIC ACIDS SYMPOSIUM SERIES, OXFORD UNIVERSITY PRESS, GB, vol. 53, no. 1, 1 September 2009 (2009-09-01), GB , pages 129 - 130, XP055331388, ISSN: 0261-3166, DOI: 10.1093/nass/nrp065
MALWINA STRENKOWSKA, KOWALSKA JOANNA, LUKASZEWICZ MACIEJ, ZUBEREK JOANNA, SU WEI, RHOADS ROBERT E., DARZYNKIEWICZ EDWARD, JEMIELIT: "Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 34, no. 5, 1 January 2010 (2010-01-01), GB , pages 993, XP055553163, ISSN: 1144-0546, DOI: 10.1039/b9nj00644c
M. ISHIKAWA, R. MURAI, H. HAGIWARA, T. HOSHINO, K. SUYAMA: "Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation", NUCLEIC ACIDS SYMPOSIUM SERIES, OXFORD UNIVERSITY PRESS, GB, vol. 53, no. 1, 1 September 2009 (2009-09-01), GB , pages 129 - 130, XP055331388, ISSN: 0261-3166, DOI: 10.1093/nass/nrp065
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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