Title:
MULTI-EPITOPE VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/236809
Kind Code:
A3
Abstract:
The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Αβ) peptide and a fau. peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or oilier diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Αβ and/or tan, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Αβ) peptide and a tau peptide.
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Inventors:
BARBOUR ROBIN (US)
KINNEY GENE (US)
ZAGO WAGNER (US)
NIJJAR TARLOCHAN (US)
KINNEY GENE (US)
ZAGO WAGNER (US)
NIJJAR TARLOCHAN (US)
Application Number:
PCT/US2021/033222
Publication Date:
December 30, 2021
Filing Date:
May 19, 2021
Export Citation:
Assignee:
OTHAIR PROTHENA LTD (IE)
BARBOUR ROBIN (US)
KINNEY GENE (US)
ZAGO WAGNER (US)
NIJJAR TARLOCHAN S (US)
BARBOUR ROBIN (US)
KINNEY GENE (US)
ZAGO WAGNER (US)
NIJJAR TARLOCHAN S (US)
International Classes:
A61K38/12; A61K39/39; A61P25/28; C07K7/06; C07K7/64; C07K19/00
Foreign References:
| US20170239349A1 | 2017-08-24 | |||
| US20140294839A1 | 2014-10-02 |
Attorney, Agent or Firm:
GATTARI, Patrick, G. (US)
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