Title:
ＣＤ１１７＋細胞を減少させるための組成物及び方法
Document Type and Number:
Japanese Patent JP7280254
Kind Code:
B2
Abstract:
The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
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Inventors:
Bradley Earl Pierce
Michael cook
Anthony Boitano
Rahul Pulchow Dury
Sean McDonough
Radib Panwar
Jacob Granville
Michael cook
Anthony Boitano
Rahul Pulchow Dury
Sean McDonough
Radib Panwar
Jacob Granville
Application Number:
JP2020523244A
Publication Date:
May 23, 2023
Filing Date:
October 23, 2018
Export Citation:
Assignee:
MAGENTA THERAPEUTICS, INC.
International Classes:
C07K16/28; A61K38/12; A61K47/68; A61P3/00; A61P7/00; A61P7/06; A61P35/00; A61P35/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP2014515030A | ||||
| JP2016536017A |
Foreign References:
| WO2008067115A2 | ||||
| WO2016142049A1 |
Attorney, Agent or Firm:
Kenji Sugimura
Mitsutsugu Sugimura
Mutsuya Yamamoto
Mitsutsugu Sugimura
Mutsuya Yamamoto