MULTI-MUTANT DIPHTHERIA TOXIN VACCINES

WIPO Patent Application WO2000048638

A3

Disclosed are diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.

COLLIER R JOHN

PCT/US2000/003735

March 01, 2001

February 14, 2000

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HARVARD COLLEGE (US)

C12N15/09; A61K39/00; A61K39/05; A61K47/48; A61P31/04; A61P37/04; C07H21/04; C07K14/255; C07K14/34; C07K16/12; C07K19/00; C12N1/15; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12P21/02; C12P21/04; C12P21/08; C12R1/01; C12R1/07; C12R1/16; C12R1/19; C12R1/42; C12R1/63; (IPC1-7): A61K47/48; C07K14/34; A61K39/05

WO1993025210A1	1993-12-23
WO1992000099A1	1992-01-09
WO1995033481A1	1995-12-14

DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAUL, POONAM ET AL: "Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin", XP002153862, retrieved from STN Database accession no. 124:253099
SHEN W H ET AL: "Participation of lysine 516 and phenylalanine 530 of diphtheria toxin in receptor recognition.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1994 NOV 18) 269 (46) 29077-84., XP002153861
TORTORELLA, DOMENICO ET AL: "Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes", J. BIOL. CHEM. (1995), 270(46), 27446-52, XP002153877

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