Title:
MULTICELLULAR TARGETING LIPOSOME
Document Type and Number:
WIPO Patent Application WO/2019/052401
Kind Code:
A1
Abstract:
The present invention falls within the field of the use of liposome preparations in the preparation of tumor drugs, and in particular relates to the construction and use of a multicellular targeting liposome. A single liposome comprises multiple antibodies against different cells and a liposome with a stable structure and long circulation characteristics in vivo is constituted by molecular self-assembly. The multicellular targeting liposome can sequentially or simultaneously bind to multiple different cells by means of the action of antibodies to promote the identification of, communication between, the cytotoxicity of, the pro-apoptosis or clearance of different cells, etc.
Inventors:
XU YUHONG (CN)
XIE FANG (CN)
XIE FANG (CN)
Application Number:
PCT/CN2018/104533
Publication Date:
March 21, 2019
Filing Date:
September 07, 2018
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
International Classes:
A61K9/127; A61K39/00; A61K39/395; A61K39/44; A61K47/00; A61P35/00
Foreign References:
| CN1116118A | 1996-02-07 | |||
| US20150071989A1 | 2015-03-12 | |||
| CN102056591A | 2011-05-11 | |||
| CN101612126A | 2009-12-30 |
Other References:
MACK, K. ET AL.: "Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv- Immunoliposomes", ANTIBODIES, 25 July 2012 (2012-07-25), pages 199 - 214, XP055356499
LAGINHA, K. ET AL.: "Liposomes Targeted via Two Different Antibodies: Assay, B- cell Binding and Cytotoxicity", BIOCHIMICA ET BIOPHYSICA ACTA, 16 March 2005 (2005-03-16), pages 25 - 32, XP027733908
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL", 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "CURRENT PROTOCOLS IN MOLECULAR BIOLOGY", 1987, JOHN WILEY & SONS
WOLFE: "CHROMATIN STRUCTURE AND FUNCTION", 1998, ACADEMIC PRESS
"METHOD IN ENZYMOLOGY", vol. 304, 1999, ACADEMIC PRESS, article "Chromatin"
"METHODS IN MOLECULAR BIOLOGY", vol. 119, 1999, HUMANA PRESS, article "Chromatin Protocols"
See also references of EP 3689336A4
LAGINHA, K. ET AL.: "Liposomes Targeted via Two Different Antibodies: Assay, B- cell Binding and Cytotoxicity", BIOCHIMICA ET BIOPHYSICA ACTA, 16 March 2005 (2005-03-16), pages 25 - 32, XP027733908
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL", 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "CURRENT PROTOCOLS IN MOLECULAR BIOLOGY", 1987, JOHN WILEY & SONS
WOLFE: "CHROMATIN STRUCTURE AND FUNCTION", 1998, ACADEMIC PRESS
"METHOD IN ENZYMOLOGY", vol. 304, 1999, ACADEMIC PRESS, article "Chromatin"
"METHODS IN MOLECULAR BIOLOGY", vol. 119, 1999, HUMANA PRESS, article "Chromatin Protocols"
See also references of EP 3689336A4
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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