Title:
Multivalent Ligand Clusters with Diamine Scaffold for Targeted Delivery of Therapeutic Agents
Document Type and Number:
WIPO Patent Application WO/2023/045995
Kind Code:
A1
Abstract:
Multivalent ligand clusters, having a diamine scaffold, for targeted delivery of pharmaceutical agents conjugated thereto are described. A multivalent ligand cluster may comprise one or more N-acetylgalactosamine (GalNAc) targeting ligands. A multivalent ligand cluster may be conjugated to one or more small interfering ribonucleic acids (siRNAs), with siRNA being an example of a pharmaceutical agent. Compositions comprising a multivalent ligand cluster, and methods of making a multivalent ligand cluster, are also described.
Inventors:
SHU DONGXU (CN)
SHAO PENGCHENG PATRICK (US)
SHAO PENGCHENG PATRICK (US)
Application Number:
PCT/CN2022/120422
Publication Date:
March 30, 2023
Filing Date:
September 22, 2022
Export Citation:
Assignee:
SHANGHAI ARGO BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/54; A61P1/16; C07H5/06; C12N15/113
Domestic Patent References:
| WO2020191183A1 | 2020-09-24 | |||
| WO2016057693A1 | 2016-04-14 | |||
| WO2011038356A2 | 2011-03-31 | |||
| WO2017177326A1 | 2017-10-19 |
Foreign References:
| CN105377887A | 2016-03-02 | |||
| US20140186262A1 | 2014-07-03 |
Other References:
VIVEK K. SHARMA, MAIRE F. OSBORN, MATTHEW R. HASSLER, DIMAS ECHEVERRIA, SOCHEATA LY, EGOR A. ULASHCHIK, YURY V. MARTYNENKO-MAKAEV,: "Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 7, 18 July 2018 (2018-07-18), US , pages 2478 - 2488, XP055556649, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00365
JAYAPRAKASH K. NAIR, JENNIFER L S WILLOUGHBY, AMY CHAN, KLAUS CHARISSE, MD ROWSHON, ALAM, QIANFAN WANG, MENNO HOEKSTRA, PACHAMUTHU: "Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 136, no. 49, 10 December 2014 (2014-12-10), pages 16958 - 16961, XP055181463, ISSN: 0002-7863, DOI: 10.1021/ja505986a
JAYAPRAKASH K. NAIR, JENNIFER L S WILLOUGHBY, AMY CHAN, KLAUS CHARISSE, MD ROWSHON, ALAM, QIANFAN WANG, MENNO HOEKSTRA, PACHAMUTHU: "Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 136, no. 49, 10 December 2014 (2014-12-10), pages 16958 - 16961, XP055181463, ISSN: 0002-7863, DOI: 10.1021/ja505986a
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
Download PDF: