Title:
NUCLEIC ACID CONSTRUCT FOR GENE THERAPY OF CARBOHYDRATE METABOLISM-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/045996
Kind Code:
A1
Abstract:
A nucleic acid construct for gene therapy of carbohydrate metabolism-related diseases. The nucleic acid construct comprises a polynucleotide encoding GLP-1 or an analogue thereof, the total number of GLP-1 or the analogue thereof is two or more, and GLP-1 and GLP-1, GLP-1 and the analogue thereof, or the GLP-1 analogue and the GLP-1 analogue are linked by means of a polynucleotide encoding a linker peptide. The nucleic acid construct can be used for high-efficiency expression of active GLP-1 and the analogue thereof in vivo and in vitro, and can be used for drug development of carbohydrate metabolism-related diseases such as type 2 diabetes, body metabolic disorder, diabetes-related complications, and obesity.
Inventors:
WU HAOQUAN (CN)
SUN BAOZHEN (CN)
DANG YING (CN)
SUN BAOZHEN (CN)
DANG YING (CN)
Application Number:
PCT/CN2022/120427
Publication Date:
March 30, 2023
Filing Date:
September 22, 2022
Export Citation:
Assignee:
KANGLIN BIOTECHNOLOGY HANGZHOU CO LTD (CN)
International Classes:
C12N15/867; A61K38/26; A61P3/04; A61P3/10; C12N5/10; C12N15/16; C12N15/864
Domestic Patent References:
| WO1995017510A1 | 1995-06-29 |
Foreign References:
| CN113846124A | 2021-12-28 | |||
| CN102690352A | 2012-09-26 | |||
| CN102690352A | 2012-09-26 | |||
| CN111072783A | 2020-04-28 | |||
| CN101273058A | 2008-09-24 |
Other References:
TASYUREK HALE M., ALTUNBAS HASAN ALI, BALCI MUSTAFA KEMAL, GRIFFITH THOMAS S., SANLIOGLU SALIH: "Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 29, no. 7, 1 July 2018 (2018-07-01), GB , pages 802 - 815, XP093053523, ISSN: 1043-0342, DOI: 10.1089/hum.2017.180
CHOI S H; LEE H C: "Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 18, no. 2, 19 August 2010 (2010-08-19), GB , pages 155 - 163, XP037772937, ISSN: 0969-7128, DOI: 10.1038/gt.2010.119
CHOI S H; LEE H C: "Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 18, no. 2, 19 August 2010 (2010-08-19), GB , pages 155 - 163, XP037772937, ISSN: 0969-7128, DOI: 10.1038/gt.2010.119
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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