MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR MODULATION OF ACVR1

Title:

MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR MODULATION OF ACVR1

Document Type and Number:

WIPO Patent Application WO/2021/142260

Kind Code:

A1

Abstract:

Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload that targets expression or activity of ACVR1. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on a muscle cell (e.g., a cardiac muscle cell). In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

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Inventors:

SUBRAMANIAN ROMESH (US)
QATANANI MOHAMMED (US)
DESJARDINS CODY (US)
BROWN DUNCAN (US)
KOTELIANSKI VICTOR (US)
WEEDEN TIMOTHY (US)
QUINN BRENDAN (US)

Application Number:

PCT/US2021/012699

Publication Date:

July 15, 2021

Filing Date:

January 08, 2021

Export Citation:

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Assignee:

DYNE THERAPEUTICS INC (US)

International Classes:

A61K39/395; A61K47/42; A61K47/68

Domestic Patent References:

WO2017197347A1	2017-11-16
WO2020028831A1	2020-02-06

Foreign References:

US20180002433A1	2018-01-04
US20180111983A1	2018-04-26
US20130039915A1	2013-02-14

Attorney, Agent or Firm:

GE, Zhiyun et al. (US)

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