Title:
NEW SODIUM CHANNEL (rNaV1.5a) AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2002002608
Kind Code:
A3
Abstract:
The present invention relates to a novel voltage gated sodium channel located in the brain, nucleotides coding for it, vectors and host cells containing the same, transgenic non-human animal capable of expressing the sodium channel, and methods of screening for modulators of the channel such as modulators for use in the treatment of seizures, and conditions related to the limbic system and limbic regions including limbic seizures.
Inventors:
KORSGAARD MADS P G (DK)
Application Number:
PCT/DK2001/000414
Publication Date:
May 10, 2002
Filing Date:
June 14, 2001
Export Citation:
Assignee:
NEUROSEARCH AS (DK)
KORSGAARD MADS P G (DK)
KORSGAARD MADS P G (DK)
International Classes:
C07K14/705; C12N15/12; (IPC1-7): C12N15/12; A61K31/00; C07K14/47; C07K14/705; C07K16/44; C12N15/63
Domestic Patent References:
| WO1999047670A1 | 1999-09-23 | |||
| WO1997001577A1 | 1997-01-16 |
Foreign References:
| US6110672A | 2000-08-29 |
Other References:
DANIEL L. BURGESS ET AL: "Mutation of a new sodium channel gene, Scn8a, in the mouse mutant "motor endplate disease"", NATURE GENETICS, vol. 10, August 1995 (1995-08-01), pages 461 - 465, XP002902044
J K J DISS ET AL: "Expression of skeletal muscle-type voltage-gated Na+ channel in rat and human prostate cancer cell lines", FEBS LETTERS, vol. 427, 1998, pages 5 - 10, XP002902045
JUAN J TOLEDO-ARAL ET AL: "Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons", PROC. NATL. ACAD. SCI., vol. 94, February 1997 (1997-02-01), pages 1527 - 1532, XP002902046
ATTICUS H HAINSWORTH ET AL: "Sipatrigine (BW 619C89) is a neuroprotective agent and sodium channel and calcium channel inhibitor", CNS DRUG REVIEWS, vol. 6, no. 2, 2000, pages 111 - 134, XP002902047
DANIEL G LANG ET AL: "Lamotrigine, Phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL, THERAPEUTICS, vol. 266, no. 2, 1993, pages 829 - 835, XP002902048
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 13 30 November 1999 (1999-11-30)
CHIUNG-MEI LU ET AL: "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit", JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 10, 1998, pages 67 - 70, XP002902049
CRISTINA ZONA ET AL: "Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture", EPILEPSIA, vol. 38, no. 5, 1997, pages 522 - 525, XP002902050
See also references of EP 1301596A2
J K J DISS ET AL: "Expression of skeletal muscle-type voltage-gated Na+ channel in rat and human prostate cancer cell lines", FEBS LETTERS, vol. 427, 1998, pages 5 - 10, XP002902045
JUAN J TOLEDO-ARAL ET AL: "Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons", PROC. NATL. ACAD. SCI., vol. 94, February 1997 (1997-02-01), pages 1527 - 1532, XP002902046
ATTICUS H HAINSWORTH ET AL: "Sipatrigine (BW 619C89) is a neuroprotective agent and sodium channel and calcium channel inhibitor", CNS DRUG REVIEWS, vol. 6, no. 2, 2000, pages 111 - 134, XP002902047
DANIEL G LANG ET AL: "Lamotrigine, Phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL, THERAPEUTICS, vol. 266, no. 2, 1993, pages 829 - 835, XP002902048
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 13 30 November 1999 (1999-11-30)
CHIUNG-MEI LU ET AL: "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit", JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 10, 1998, pages 67 - 70, XP002902049
CRISTINA ZONA ET AL: "Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture", EPILEPSIA, vol. 38, no. 5, 1997, pages 522 - 525, XP002902050
See also references of EP 1301596A2
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