Title:
NOVEL beta-LACTAM COMPOUND AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/1994/029313
Kind Code:
A1
Abstract:
A novel beta-lactam compound represented by general formula [1] and having an excellent antibacterial activity against gram-positive bacteria, in particular, methicillin-resistant staphylococci and methicillin-resistant coagulase-negative staphylococci, a pharmaceutically acceptable salt thereof, and a process for producing the same, wherein R1 represents lower alkyl which may be hydroxylated; R2 represents hydrogen or lower alkyl; X represents oxygen, sulfur or NH; Y represents nitrogen or carbon, provided n is 0 when Y represents nitrogen and n is 1 when Y represents carbon; and Z represents (each independently when n is 1) hydrogen, Ra (lower alkyl, etc.), A (aryl, etc.), -OH, -ORa, -OA, -SRa, -SA, -NH2, -NHRa, -NRbRc (Rb and Rc being each lower alkyl, etc.), -NHA, -NRaA, -CONH2, -CONHRa, -CONRbRa, -CONHA, -CONRaA, -CONHC(NH)NH2, -COOH, -COORa, -COOA, -CORa, -COA, halogen, or cyano.
Inventors:
SUNAGAWA MAKOTO (JP)
YAMAGA HIROSHI (JP)
SUMITA YOSHIHIRO (JP)
YAMAGA HIROSHI (JP)
SUMITA YOSHIHIRO (JP)
Application Number:
PCT/JP1994/000958
Publication Date:
December 22, 1994
Filing Date:
June 14, 1994
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
SUNAGAWA MAKOTO (JP)
YAMAGA HIROSHI (JP)
SUMITA YOSHIHIRO (JP)
SUNAGAWA MAKOTO (JP)
YAMAGA HIROSHI (JP)
SUMITA YOSHIHIRO (JP)
International Classes:
C07D477/20; C07D521/00; (IPC1-7): C07D477/00
Foreign References:
| JPS5826887A | 1983-02-17 | |||
| JPS60233077A | 1985-11-19 | |||
| JPS615081A | 1986-01-10 | |||
| JPS6363680A | 1988-03-22 | |||
| JPS63145280A | 1988-06-17 |
Other References:
See also references of EP 0704446A4
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