Title:
NANOBODY TARGETING CD73, NANOBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246325
Kind Code:
A1
Abstract:
Disclosed are a nanobody (Nb) targeting CD73, a nanobody-drug conjugate (NDC), a preparation method therefor and use thereof. The monoclonal nanobody and the corresponding NDC of the present invention can efficiently and specifically bind to purified CD73 proteins, various tumor cells and CD73 on surfaces of immune cells and block the catalytic activity of a CD73 enzyme, has very high affinity and very low immunogenicity, and has a remarkable anti-tumor effect.
Inventors:
YU KE (CN)
LIU LIANG (CN)
MENG TAO (CN)
LIU LIANG (CN)
MENG TAO (CN)
Application Number:
PCT/CN2023/092108
Publication Date:
December 28, 2023
Filing Date:
May 04, 2023
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
A61K47/68; C07K16/28; A61P35/00; A61P35/04; C07K16/46; C07K19/00; C12N5/10; C12N15/85
Foreign References:
| CN110240654A | 2019-09-17 | |||
| CN111434688A | 2020-07-21 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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