Title:
PHOTOSENSITIZER/METAL NANOPARTICLE CHARGE COMPLEX AND COMPOSITION CONTAINING THE COMPLEX FOR PHOTODYNAMIC THERAPY OR DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2011/049256
Kind Code:
A1
Abstract:
Disclosed are a photosensitizer/metal nanoparticle charge complex and a composition containing the complex for photodynamic therapy or diagnosis. The complex comprises: a metal nanoparticle; a photosensitizer having a first charge; and a connecting portion coupled to the metal nanoparticle and having a second charge, the polarity of which is opposite to the first charge. While the photosensitizer/metal nanoparticle charge complex circulates within the blood, the complex can be maintained to reduce the prolongation of photosensitivity-related side effects. Also, as the complex specifically tends to accumulate in tumorous tissue but cannot easily infiltrate normal tissue, the use of photodynamic treatment can effectively destroy only tumorous tissue. Furthermore, the selective use of fluorescent markers in tumorous tissue can increase the accuracy of tumor diagnosis using the complex.
Inventors:
CHOI YONG-DOO (KR)
JANG BO-SEUNG (KR)
PARK JIN-YOUNG (KR)
LEE JUNG-IM (KR)
KIM IN-HOO (KR)
JANG BO-SEUNG (KR)
PARK JIN-YOUNG (KR)
LEE JUNG-IM (KR)
KIM IN-HOO (KR)
Application Number:
PCT/KR2009/006263
Publication Date:
April 28, 2011
Filing Date:
October 28, 2009
Export Citation:
Assignee:
NAT CANCER CT (KR)
CHOI YONG-DOO (KR)
JANG BO-SEUNG (KR)
PARK JIN-YOUNG (KR)
LEE JUNG-IM (KR)
KIM IN-HOO (KR)
CHOI YONG-DOO (KR)
JANG BO-SEUNG (KR)
PARK JIN-YOUNG (KR)
LEE JUNG-IM (KR)
KIM IN-HOO (KR)
International Classes:
A61K49/00; A61K33/06; A61K33/242; A61K47/48; A61P35/00
Foreign References:
| KR20070118501A | 2007-12-17 | |||
| KR100809402B1 | 2008-03-05 | |||
| US20090060840A1 | 2009-03-05 | |||
| US20010022963A1 | 2001-09-20 |
Other References:
TSAY, M. JAMES ET AL.: "Singlet Oxygen Production by Peptide-Coated Quantum Dot- Photosensitizer Conjugates.", J. AM. CHEM. SOC., vol. 129, 2007, pages 6865 - 6871
BECHET, DENISE ET AL.: "Nanoparticles as vehicles for delivery of photodynamic therapy agents.", TRENDS IN BIOTECHNOLOGY, vol. 26, no. 11, November 2008 (2008-11-01), pages 612 - 621
HONE, C. DUNCAN ET AL.: "Generation of Cytotoxic Singlet Oxygen via Phthalocyanine- Stabilized Gold Nanoparticles: A PotentialDelivery Vehicle for Photodynamic Therapy.", LANGMUIR, vol. 18, 2002, pages 2985 - 2987, XP002245879, DOI: doi:10.1021/la0256230
BECHET, DENISE ET AL.: "Nanoparticles as vehicles for delivery of photodynamic therapy agents.", TRENDS IN BIOTECHNOLOGY, vol. 26, no. 11, November 2008 (2008-11-01), pages 612 - 621
HONE, C. DUNCAN ET AL.: "Generation of Cytotoxic Singlet Oxygen via Phthalocyanine- Stabilized Gold Nanoparticles: A PotentialDelivery Vehicle for Photodynamic Therapy.", LANGMUIR, vol. 18, 2002, pages 2985 - 2987, XP002245879, DOI: doi:10.1021/la0256230
Attorney, Agent or Firm:
E-SANG PATENT & TRADEMARK LAW FIRM (KR)
특허법인 이상 (KR)
특허법인 이상 (KR)
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