Title:
NANOPARTICLES WITH SPECIAL COATING AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/054526
Kind Code:
A1
Abstract:
The present invention relates to nanoparticles for immunotherapy and to a pharmaceutical composition comprising NK cells and the nanoparticles. According to one aspect, by means of the nanoparticles, a gene can be delivered to and expressed in immune cells, and the NK cells having the nanoparticles incorporated therein can effectively treat cancer without adverse side effects of existing CAR T cells and enable cell tracking at the same time.
Inventors:
PARK KYUNG SOON (KR)
PARK WOO RAM (KR)
HAN DONG KEUN (KR)
AN HEE JUNG (KR)
KIM KWANG SOO (KR)
HAN JUN HYEOK (KR)
PARK WOO RAM (KR)
HAN DONG KEUN (KR)
AN HEE JUNG (KR)
KIM KWANG SOO (KR)
HAN JUN HYEOK (KR)
Application Number:
PCT/KR2019/016554
Publication Date:
March 25, 2021
Filing Date:
November 28, 2019
Export Citation:
Assignee:
SUNGKWANG MEDICAL FOUND (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
A61K9/51; A61K31/7088; A61K39/00; A61K45/06; A61P35/00
Domestic Patent References:
| WO2012177986A2 | 2012-12-27 |
Foreign References:
| US20180022604A1 | 2018-01-25 |
Other References:
KYUNG-SOON PARK; PARK WOO-RAM; DONG-GEUN HAN: "Development of Technology of Natural Killer Cell Attacking Cancer Cell", 26 August 2019 (2019-08-26), pages 1 - 6, XP009526960, Retrieved from the Internet
ARRIAGADA FRANCISCO, GÜNTHER GERMÁN, NOS JAUME, NONELL SANTI, OLEA-AZAR CLAUDIO, MORALES JAVIER: "Antioxidant Nanomaterial Based on Core–Shell Silica Nanospheres with Surface-Bound Caffeic Acid: A Promising Vehicle for Oxidation-Sensitive Drugs", NANOMATERIALS, vol. 9, no. 2, pages 214, XP055793153, DOI: 10.3390/nano9020214
ZHANG YU, ZHONG YIXIN, YE MAN, XU JIE, LIU JIA, ZHOU JUN, WANG SHIKE, GUO DAJING, WANG ZHIGANG, RAN HAITAO: "Polydopamine-modified dual-ligand nanoparticles as highly effective and targeted magnetic resonance/photoacoustic dual-modality thrombus imaging agents", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. Volume 14, pages 7155 - 7171, XP055793151, DOI: 10.2147/IJN.S216603
KIM KWANG-SOO; HAN JUN-HYEOK; PARK JUNG-HOON; KIM HYUNG-KEUN; CHOI SEUNG HEE; KIM GYEONG RYEONG; SONG HAENGSEOK; AN HEE JUNG; HAN : "Multifunctional nanoparticles for genetic engineering and bioimaging of natural killer (NK) cell therapeutics", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 221, 9 August 2019 (2019-08-09), AMSTERDAM, NL, XP085798305, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119418
ARRIAGADA FRANCISCO, GÜNTHER GERMÁN, NOS JAUME, NONELL SANTI, OLEA-AZAR CLAUDIO, MORALES JAVIER: "Antioxidant Nanomaterial Based on Core–Shell Silica Nanospheres with Surface-Bound Caffeic Acid: A Promising Vehicle for Oxidation-Sensitive Drugs", NANOMATERIALS, vol. 9, no. 2, pages 214, XP055793153, DOI: 10.3390/nano9020214
ZHANG YU, ZHONG YIXIN, YE MAN, XU JIE, LIU JIA, ZHOU JUN, WANG SHIKE, GUO DAJING, WANG ZHIGANG, RAN HAITAO: "Polydopamine-modified dual-ligand nanoparticles as highly effective and targeted magnetic resonance/photoacoustic dual-modality thrombus imaging agents", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. Volume 14, pages 7155 - 7171, XP055793151, DOI: 10.2147/IJN.S216603
KIM KWANG-SOO; HAN JUN-HYEOK; PARK JUNG-HOON; KIM HYUNG-KEUN; CHOI SEUNG HEE; KIM GYEONG RYEONG; SONG HAENGSEOK; AN HEE JUNG; HAN : "Multifunctional nanoparticles for genetic engineering and bioimaging of natural killer (NK) cell therapeutics", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 221, 9 August 2019 (2019-08-09), AMSTERDAM, NL, XP085798305, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119418
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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