Title:
NATURAL ANTITUMOR OR ANTIVIRAL SUBSTANCES AND USE OF THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/055493
Kind Code:
A1
Abstract:
Antitumor or antiviral substances represented by general formula (1) or pharmaceutically acceptable salts thereof, being efficacious against cancers and viruses on which the existing antitumor agents and antiviral agents cannot exert sufficient effects, exhibiting carcinostatic and antiviral effects on various tolerant cancers, and having relieved side effects without damaging normal human cells. In said formula, R1 represents a nucleic acid base represented by a specific formula; and R2 represents hydrogen, hydroxy or methoxy. A process for producing the substances represented by formula (1) or pharmaceutically acceptable salts thereof, which comprises culturing NS cells capable of producing the compounds of formula (1) and taking up the compounds of formula (1) from the culture medium and optionally converting the same into pharmaceutically acceptable salts thereof. Drugs containing the above compounds as the active ingredients and CD57-positive and strongly HLA.DR- positive human natural suppressor cells.
Inventors:
MORI TSUNEATSU (JP)
GUO MAOWU (CA)
MORI ETSUKO (JP)
GUO MAOWU (CA)
MORI ETSUKO (JP)
Application Number:
PCT/JP1998/002438
Publication Date:
December 10, 1998
Filing Date:
June 02, 1998
Export Citation:
Assignee:
TECHNO SEVEN CO LTD (JP)
MORI TSUNEATSU (JP)
GUO MAOWU (CA)
MORI ETSUKO (JP)
MORI TSUNEATSU (JP)
GUO MAOWU (CA)
MORI ETSUKO (JP)
International Classes:
A61K35/50; A61P35/00; C07H19/04; C07H19/167; C12N5/071; C12P19/38; A61K31/7052; (IPC1-7): C07H19/06; C07H19/073; C07H19/16; C07H19/173; C12N5/08; A61K31/70; C12P19/38; C12P19/40
Foreign References:
| JPS61291595A | 1986-12-22 | |||
| JPS6223725B2 | 1987-05-25 | |||
| JPS6223723B2 | 1987-05-25 | |||
| JPH01125325A | 1989-05-17 | |||
| JPH04252190A | 1992-09-08 | |||
| JPS6214794A | 1987-01-23 |
Other References:
LOTHROP C. D., UZIEL M.: "RNA TURNOVER IN CULTURED HAMSTER EMBRYO CELLS: IDENTIFICATION OF MODIFIED NUCLEOSIDE END PRODUCTS.", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 114., 1 January 1983 (1983-01-01), US, pages 111 - 116., XP002913101, ISSN: 0021-9541, DOI: 10.1002/jcp.1041140118
CRAMER H., PFLEIDERER W.: "A SIMPLE PROCEDURE FOR THE MONOMETHYLATION OF PROTECTED AND UNPROTECTED RIBONUCLEOSIDES IN THE 2 -O- AND 3 O-POSITION USING DIAZOMETHANE AND THE CATALYST STANNOUS CHLORIDE.", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., CH, vol. 79., 1 January 1996 (1996-01-01), CH, pages 2114 - 2136., XP002913102, ISSN: 0018-019X, DOI: 10.1002/hlca.19960790808
MORI T., ET AL.: "STUDIES OF MAMMALIAN IMPLANTATION IN VITRO (I): PRODUCTION OF LAMIMIN FROM HUMAN DECIDUAL CELL LINE AND ITS EFFETS ON MURINE TROPHOBLASTIC OUTGROWTH.", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 38., no. 04., 1 January 1992 (1992-01-01), JP, pages 285 - 292., XP002913103, ISSN: 0916-8818
CRAMER H., PFLEIDERER W.: "A SIMPLE PROCEDURE FOR THE MONOMETHYLATION OF PROTECTED AND UNPROTECTED RIBONUCLEOSIDES IN THE 2 -O- AND 3 O-POSITION USING DIAZOMETHANE AND THE CATALYST STANNOUS CHLORIDE.", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., CH, vol. 79., 1 January 1996 (1996-01-01), CH, pages 2114 - 2136., XP002913102, ISSN: 0018-019X, DOI: 10.1002/hlca.19960790808
MORI T., ET AL.: "STUDIES OF MAMMALIAN IMPLANTATION IN VITRO (I): PRODUCTION OF LAMIMIN FROM HUMAN DECIDUAL CELL LINE AND ITS EFFETS ON MURINE TROPHOBLASTIC OUTGROWTH.", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 38., no. 04., 1 January 1992 (1992-01-01), JP, pages 285 - 292., XP002913103, ISSN: 0916-8818
Attorney, Agent or Firm:
Sato, Kazuo (Fuji Building Room 323, 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)
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