Title:
NEEDLE-MEDICINE INTEGRATED HYDROGEL MICRONEEDLE
Document Type and Number:
WIPO Patent Application WO/2023/098158
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines. Disclosed is a needle-medicine integrated hydrogel microneedle. A microneedle matrix is hydrogel formed by a gelatin and tannic acid cross-linked product, a medicine is entrapped in the matrix, and the medicine is cinnamon oil nanocapsules (CIO@NCs). The cinnamon oil nanocapsule hydrogel microneedle (HFMNs-CIO@NCs) can better entrap the CIO@NCs and deliver the CIO@NCs to the deep layer of the skin in an acupoint area to fully exert the effect of warming spleen and stomach for dispelling cold of cinnamon oil; and moreover, the microneedle itself absorbs water to swell, and can stimulate the tissue in the Shenque acupoint area to excite an acupoint area effect, thereby improving symptoms of cold coagulation of a cold coagulation and blood stasis type dysmenorrhea model rat. The needle-medicine integrated hydrogel microneedle can be used for various entrapment medicines and preparations thereof, is further used for clinical treatment of acupoint therapy, and has clinical popularization and use values.
Inventors:
ZHANG YONGTAI (CN)
FENG NIANPING (CN)
HOU XIAOLIN (CN)
WANG ZHI (CN)
GUO TENG (CN)
FENG NIANPING (CN)
HOU XIAOLIN (CN)
WANG ZHI (CN)
GUO TENG (CN)
Application Number:
PCT/CN2022/114243
Publication Date:
June 08, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
UNIV SHANGHAI TRADITIONAL CHINESE MEDICINE (CN)
International Classes:
A61H39/00; A61K9/00; A61K9/51; A61K36/54; A61K47/22; A61K47/36; A61K47/42; A61M37/00; A61P15/00; A61P29/00
Foreign References:
| CN114146048A | 2022-03-08 | |||
| CN108245481A | 2018-07-06 | |||
| US20210322743A1 | 2021-10-21 |
Other References:
CAO, N. FU, Y. HE, J.: "Mechanical properties of gelatin films cross-linked, respectively, by ferulic acid and tannin acid", FOOD HYDROCOLLOIDS, ELSEVIER BV, NL, vol. 21, no. 4, 16 January 2007 (2007-01-16), NL , pages 575 - 584, XP005736324, ISSN: 0268-005X, DOI: 10.1016/j.foodhyd.2006.07.001
ZHANG, YONGTAI: "A Therapeutic Strategy of Combining Acupuncture and Drug Delivery at the Same Acupuncture Point-Taking Umbilical Therapy as an Example", CHINA'S NATUROPATHY, vol. 28, no. 5, 31 March 2020 (2020-03-31), XP009546872
ZHANG, YONGTAI: "A Therapeutic Strategy of Combining Acupuncture and Drug Delivery at the Same Acupuncture Point-Taking Umbilical Therapy as an Example", CHINA'S NATUROPATHY, vol. 28, no. 5, 31 March 2020 (2020-03-31), XP009546872
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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