Title:
NEPHROTOXICITY REDUCING AGENT
Document Type and Number:
WIPO Patent Application WO/2023/282344
Kind Code:
A1
Abstract:
[Problem] In an embodiment, the present invention addresses the problem of providing a nephrotoxicity reducing agent for a medical composition including an antisense oligomer, and a method for reducing nephrotoxicity of said medical composition. [Solution] In an embodiment, the present invention relates to a nephrotoxicity reducing agent for a medical composition including an antisense oligomer, the nephrotoxicity reducing agent including a sugar alcohol and being used in an amount such that the concentration of the sugar alcohol in the medical composition is 1-400 mg/mL.
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Inventors:
SONOKE SATORU (JP)
FUJIWARA KAE (JP)
SATOU YOUHEI (JP)
WAKAYAMA TATSUSHI (JP)
MASUDA HIROFUMI (JP)
SEKI RYOSUKE (JP)
MATSUBARA TAKUMA (JP)
NUMAKURA YUKI (JP)
OKAMOTO KENTARO (JP)
TODA TATSUSHI (JP)
IKEDA MARIKO (JP)
KOBAYASHI KAZUHIRO (JP)
FUJIWARA KAE (JP)
SATOU YOUHEI (JP)
WAKAYAMA TATSUSHI (JP)
MASUDA HIROFUMI (JP)
SEKI RYOSUKE (JP)
MATSUBARA TAKUMA (JP)
NUMAKURA YUKI (JP)
OKAMOTO KENTARO (JP)
TODA TATSUSHI (JP)
IKEDA MARIKO (JP)
KOBAYASHI KAZUHIRO (JP)
Application Number:
PCT/JP2022/027103
Publication Date:
January 12, 2023
Filing Date:
July 08, 2022
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
UNIV KOBE NAT UNIV CORP (JP)
UNIV KOBE NAT UNIV CORP (JP)
International Classes:
A61K31/047; A61K31/7088; A61K31/712; A61K31/7125; A61K47/26; A61P13/12; A61P39/02; C12N15/113
Domestic Patent References:
| WO2010009038A2 | 2010-01-21 | |||
| WO1991009033A1 | 1991-06-27 | |||
| WO2009064471A1 | 2009-05-22 | |||
| WO2013100190A1 | 2013-07-04 | |||
| WO2008036127A2 | 2008-03-27 | |||
| WO2009005793A2 | 2009-01-08 | |||
| WO2012150960A1 | 2012-11-08 | |||
| WO2017500856A1 | ||||
| WO2015089487A1 | 2015-06-18 | |||
| WO2016187425A1 | 2016-11-24 | |||
| WO2018118662A1 | 2018-06-28 | |||
| WO2018118599A1 | 2018-06-28 | |||
| WO2018118627A1 | 2018-06-28 | |||
| WO2009073809A2 | 2009-06-11 | |||
| WO2013075035A1 | 2013-05-23 | |||
| WO2015105083A1 | 2015-07-16 | |||
| WO2014179620A1 | 2014-11-06 | |||
| WO2015006740A2 | 2015-01-15 | |||
| WO2017010575A1 | 2017-01-19 |
Foreign References:
| JP2015091229A | 2015-05-14 | |||
| JP2011528657A | 2011-11-24 | |||
| JP2004512383A | 2004-04-22 | |||
| JP2015091229A | 2015-05-14 | |||
| US20020036767A1 | 2002-03-28 | |||
| JP2006129594A | 2006-05-08 | |||
| JP2006038608A | 2006-01-20 |
Other References:
HEEMSKERK HADE WINTER CLDE KIMPE SJVAN KUIK-ROMEIJN PHEUVELMANS NPLATENBURG GJVAN OMMEN GJVAN DEUTEKOM JCAARTSMA-RUS A: "In vivo comparison of 2'-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping", J GENE MED., vol. 11, no. 3, March 2009 (2009-03-01), pages 257 - 66
SAZANI PNESS KPWELLER DLPOAGE DNELSON KSHREWSBURY AS: "Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice", INT J TOXICOL, vol. 30, no. 3, May 2011 (2011-05-01), pages 322 - 33, XP009510407, DOI: 10.1177/1091581811403504
CARVER MPCHARLESTON JSSHANKS CZHANG JMENSE MSHARMA AKKAUR HSAZANI P: "Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates", J NEUROMUSCUL DIS, vol. 3, no. 3, 30 August 2016 (2016-08-30), pages 361 - 393, XP009510433, DOI: 10.3233/JND-160157
ENYA ET AL., BIOORGANIC MEDICINAL CHEMISTRY, vol. 18, 2008, pages 9154 - 9160
P. E. NIELSENM. EGHOLMR. H. BERGO. BUCHARDT, SCIENCE, vol. 254, 1991, pages 1497
M. EGHOLMO. BUCHARDTP. E. NIELSENR. H. BERG, JACS, vol. 114, 1992, pages 1895
O. BUCHARDT, J. ORG. CHEM., vol. 59, 1994, pages 5767
H. F. HANSENT. KOCHM. EGHOLMO. BUCHARDTP. E. NIELSENJ. COULLR. H. BERG, J. PEPT. SCI., vol. 1, 1995, pages 175
T. KOCHH. F. HANSENP. ANDERSENT. LARSENH. G. BATZK. OTTESONH. ORUM, J. PEPT. RES., vol. 49, 1997, pages 80
ALTSCHUL: "BLAST (Basic Local Alignment Search Tool", PROC. NATL. ACAD. SCI. USA, 1990, pages 872264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
"GenBank", Database accession no. AB038490
HUM MOL GENET, vol. 20, no. 16, 15 August 2011 (2011-08-15), pages 3151 - 3160
PHARMACOLOGY & THERAPEUTICS, vol. 154, 2015, pages 78 - 86
EBIOMEDICINE, vol. 45, 2019, pages 630 - 645
SAZANI PNESS KPWELLER DLPOAGE DNELSON KSHREWSBURY AS: "Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice", INT J TOXICOL, vol. 30, no. 3, May 2011 (2011-05-01), pages 322 - 33, XP009510407, DOI: 10.1177/1091581811403504
CARVER MPCHARLESTON JSSHANKS CZHANG JMENSE MSHARMA AKKAUR HSAZANI P: "Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates", J NEUROMUSCUL DIS, vol. 3, no. 3, 30 August 2016 (2016-08-30), pages 361 - 393, XP009510433, DOI: 10.3233/JND-160157
ENYA ET AL., BIOORGANIC MEDICINAL CHEMISTRY, vol. 18, 2008, pages 9154 - 9160
P. E. NIELSENM. EGHOLMR. H. BERGO. BUCHARDT, SCIENCE, vol. 254, 1991, pages 1497
M. EGHOLMO. BUCHARDTP. E. NIELSENR. H. BERG, JACS, vol. 114, 1992, pages 1895
O. BUCHARDT, J. ORG. CHEM., vol. 59, 1994, pages 5767
H. F. HANSENT. KOCHM. EGHOLMO. BUCHARDTP. E. NIELSENJ. COULLR. H. BERG, J. PEPT. SCI., vol. 1, 1995, pages 175
T. KOCHH. F. HANSENP. ANDERSENT. LARSENH. G. BATZK. OTTESONH. ORUM, J. PEPT. RES., vol. 49, 1997, pages 80
ALTSCHUL: "BLAST (Basic Local Alignment Search Tool", PROC. NATL. ACAD. SCI. USA, 1990, pages 872264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
"GenBank", Database accession no. AB038490
HUM MOL GENET, vol. 20, no. 16, 15 August 2011 (2011-08-15), pages 3151 - 3160
PHARMACOLOGY & THERAPEUTICS, vol. 154, 2015, pages 78 - 86
EBIOMEDICINE, vol. 45, 2019, pages 630 - 645
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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