Title:
NEUROPROTECTIVE SYNERGY OF ERYTHROPOIETIN AND INSULIN-LIKE GROWTH FACTOR
Document Type and Number:
WIPO Patent Application WO2003103608
Kind Code:
A3
Abstract:
The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuropotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a does of at most 200 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathicpain, migraine, glaucoma, drug addition, drug withdrawal, drug dependency, depression or anxiety.
Inventors:
DIGICAYLIOGLU MURAT (US)
LIPTON STUART A (US)
LIPTON STUART A (US)
Application Number:
PCT/US2003/018645
Publication Date:
July 01, 2004
Filing Date:
June 11, 2003
Export Citation:
Assignee:
BURNHAM INST (US)
DIGICAYLIOGLU MURAT (US)
LIPTON STUART A (US)
DIGICAYLIOGLU MURAT (US)
LIPTON STUART A (US)
International Classes:
A61K38/22; A61K38/27; A61K38/30; A61P9/10; A61P21/02; A61P25/00; C12N15/09; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/36; A61P27/06; A61P31/18; A61P43/00; C07K7/08; C07K14/505; C07K14/65; (IPC1-7): G01N33/53; A61K38/00; A61K38/22; A61K38/30; C07K1/00; C07K7/00
Foreign References:
| US6165783A | 2000-12-26 | |||
| US5652214A | 1997-07-29 | |||
| US5767078A | 1998-06-16 | |||
| US5885962A | 1999-03-23 |
Other References:
See also references of EP 1535065A4
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