Title:
VIRAL ENVELOPE MEDIATED FUSION ASSAY
Document Type and Number:
WIPO Patent Application WO2003103607
Kind Code:
A3
Abstract:
This invention provides a method of screening a sample for susceptibility to a viral entry inhibitor. The invention further provides a method for monitoring a patient for sensitivity to a viral entry inhibitor and a method of determining an inhibitory concentration of a viral entry inhibitor to inhibit virus infection in a patient. A method of screening for viral entry inhibitors is also provided.
Inventors:
LIN PIN-FANG (US)
DEMINIE CAROL (US)
FRIDELL ROBERT A (US)
ROBINSON BRETT (US)
ROSE RONALD E (US)
DEMINIE CAROL (US)
FRIDELL ROBERT A (US)
ROBINSON BRETT (US)
ROSE RONALD E (US)
Application Number:
PCT/US2003/018556
Publication Date:
April 22, 2004
Filing Date:
June 11, 2003
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
LIN PIN-FANG (US)
DEMINIE CAROL (US)
FRIDELL ROBERT A (US)
ROBINSON BRETT (US)
ROSE RONALD E (US)
LIN PIN-FANG (US)
DEMINIE CAROL (US)
FRIDELL ROBERT A (US)
ROBINSON BRETT (US)
ROSE RONALD E (US)
International Classes:
C12N5/08; C12N5/22; G01N33/50; (IPC1-7): G01N33/567; G01N33/569; G01N33/53; G01N33/573; C12N5/00; C12N5/08; C12N5/10; C12N5/22
Other References:
LI B.: "The synthetic peptide WKYMVm attenuates the function of the chemokine receptor CCR5 and CXCR4 through activation of formyl peptide receptor-like 1", BLOOD, vol. 97, no. 10, 25 May 2001 (2001-05-25), pages 2941 - 2947, XP002972742
DEY B.: "Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses", J. VIROL., vol. 74, no. 10, May 2000 (2000-05-01), pages 4562 - 4569, XP002972743
NUSSBAAUM O.: "Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation", J. VIROL., vol. 68, no. 9, September 1994 (1994-09-01), pages 5411 - 5422, XP002031516
TAKASHIMA K.: "Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 12, December 2001 (2001-12-01), pages 3538 - 3543, XP002972744
DEY B.: "Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses", J. VIROL., vol. 74, no. 10, May 2000 (2000-05-01), pages 4562 - 4569, XP002972743
NUSSBAAUM O.: "Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation", J. VIROL., vol. 68, no. 9, September 1994 (1994-09-01), pages 5411 - 5422, XP002031516
TAKASHIMA K.: "Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 12, December 2001 (2001-12-01), pages 3538 - 3543, XP002972744
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