Title:
NEW CRYSTAL FORM OF DELAFLOXACIN MEGLUMINE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/137966
Kind Code:
A1
Abstract:
The present invention provides a new crystal form of delafloxacin meglumine and a preparation method therefor. An X-ray powder diffraction pattern thereof has diffraction peaks at the following angles of 2θ: 7.323 ±0.2º, 8.079 ±0.2º, 8.377 ±0.2º, 9.539 ±0.2º, 15.139 ±0.2º and 18.422 ±0.2º. The preparation method therefor comprises the following steps: taking a crude product of delafloxacin meglumine and dissolving same in a mixed solvent of alcohol and an ester/ketone/ether/alkane, stirring same, performing membrane filtering, precipitating a solid therefrom, filtering same, and drying the material so as to obtain the new type crystal form of delafloxacin meglumine. The new crystal form of delafloxacin meglumine provided by the present invention has good preparation stability and storage stability, and can adapt to environmental conditions of wider manufacturing, storage and transportation; and a preparation thereof can better withstand problems such as uneven pharmaceutical active ingredients and reduced purity which may be generated by factors of temperature, humidity, crystal form change, etc., reducing the risk of a reduction in efficacy and safety risks brought about thereby, thus being more suitable for being applied to tablets and industrialization, and has high industrial application and economic value.
Inventors:
ZHU YIFAN (CN)
FAN MINHUA (CN)
LI KAI (CN)
LIANG BEIBEI (CN)
ZHOU SHENGJUN (CN)
FAN MINHUA (CN)
LI KAI (CN)
LIANG BEIBEI (CN)
ZHOU SHENGJUN (CN)
Application Number:
PCT/CN2022/099996
Publication Date:
July 27, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
HAINAN POLY PHARM CO LTD (CN)
ZHEJIANG PULI PHARMACEUTICAL CO LTD (CN)
ANHUI PULI PHARMACEUTICAL CO LTD (CN)
ZHEJIANG PULI PHARMACEUTICAL CO LTD (CN)
ANHUI PULI PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4709; A61P31/04; C07D401/14
Foreign References:
| CN111718329A | 2020-09-29 | |||
| CN106256824A | 2016-12-28 | |||
| CN105693695A | 2016-06-22 | |||
| CN105017223A | 2015-11-04 | |||
| CN110467600A | 2019-11-19 |
Attorney, Agent or Firm:
BEIJING WITAL PATENT AGENCY CO., LTD (CN)
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