Title:
NEW NK3 RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2015/083816
Kind Code:
A1
Abstract:
Provided is a new NK3 receptor selective ligand which is expected to have high activity and high selectivity, and to act in a sustained manner in vivo. A compound expressed by formula (I) X1 - A2 - A3 - X4 - X5 - Met - NH2 [the symbols in the formula are as set forth in the description] or a pharmaceutically acceptable salt thereof has a highly active and highly selective NK3 receptor agonist activity, and is effective as a drug for the treatment of disorders associated with an excess or deficiency in the secretion of tachykinins, for example as a pharmaceutical for the treatment of pain or for the improvement of sexual dysfunction accompanying excess or deficiency in the secretion of sex hormones.
Inventors:
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MISU RYOSUKE (JP)
YAMADA AI (JP)
YAMAMOTO KOKI (JP)
OKAMURA HIROAKI (JP)
YAMAMURA TAKASHI (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MISU RYOSUKE (JP)
YAMADA AI (JP)
YAMAMOTO KOKI (JP)
OKAMURA HIROAKI (JP)
YAMAMURA TAKASHI (JP)
Application Number:
PCT/JP2014/082217
Publication Date:
June 11, 2015
Filing Date:
December 05, 2014
Export Citation:
Assignee:
UNIV KYOTO (JP)
NAT INST OF AGROBIO SCIENCES (JP)
NAT INST OF AGROBIO SCIENCES (JP)
International Classes:
C07K7/06; A61K38/00; A61P5/24; A61P15/00; A61P25/04; A61P29/02; A61P43/00; C07K5/107; C07K5/113
Domestic Patent References:
| WO1994009031A1 | 1994-04-28 | |||
| WO2014061772A1 | 2014-04-24 |
Other References:
ALMEIDA, T.A. ET AL.: "Tachykinins and tachykinin receptors: structure and activity relationships", CURRENT MEDICINAL CHEMISTRY, vol. 11, no. 15, August 2004 (2004-08-01), pages 2045 - 2081, XP002459773
MISU, R. ET AL.: "Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 8, pages 2413 - 2417, XP028524303, DOI: doi:10.1016/j.bmc.2013.01.036
MISU, R. ET AL.: "Development of Novel Neurokinin 3 Receptor (NK3R) Selective Agonists with Resistance to Proteolytic Degradation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 23 September 2014 (2014-09-23), pages 8646 - 8651
MISU, R. ET AL.: "Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 8, pages 2413 - 2417, XP028524303, DOI: doi:10.1016/j.bmc.2013.01.036
MISU, R. ET AL.: "Development of Novel Neurokinin 3 Receptor (NK3R) Selective Agonists with Resistance to Proteolytic Degradation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 23 September 2014 (2014-09-23), pages 8646 - 8651
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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