Title:
NICOTINAMIDE MONONUCLEOTIDE COMPOSITE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/037484
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biopharmaceutical preparation, and in particular to a nicotinamide mononucleotide composite and a preparation method therefor. Nicotinamide mononucleotide (NMN) has been shown to be capable of reducing cellular oxidative stress to alleviate aging-related mitochondrial dysfunction. To solve the problems of poor NMN stability and low bioavailability, natural ovalbumin (OVA) and fucoidin are self-assembled in the absence of any chemical substance by means of electrostatic and hydrophobic interactions to prepare a steady-state carrying system. Moreover, compared with free NMN, OFNPs with encapsulated NMN show significant controlled-release capacities in simulated digestion processes, and effectively ease cellular senescence and reduce lipofuscin accumulation in nematodes. Therefore, it has been demonstrated that OFNPs can be used as a potential steady-state carrying system to improve the stability and anti-aging activity of NMN.
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Inventors:
TAN MINGQIAN (CN)
SUN SHAN (CN)
PENG QIHUI (CN)
ZHU BEIWEI (CN)
XIANG SIYUAN (CN)
ZHANG XUEDI (CN)
WANG HAITAO (CN)
CHENG SHASHA (CN)
SU WENTAO (CN)
SUN SHAN (CN)
PENG QIHUI (CN)
ZHU BEIWEI (CN)
XIANG SIYUAN (CN)
ZHANG XUEDI (CN)
WANG HAITAO (CN)
CHENG SHASHA (CN)
SU WENTAO (CN)
Application Number:
PCT/CN2023/112847
Publication Date:
February 22, 2024
Filing Date:
August 14, 2023
Export Citation:
Assignee:
JIANGSU BLUE REGALE CLINICAL NUTRITION TECH CO LTD (CN)
International Classes:
A61K31/706; A61K47/36; A61K47/42; A61P39/00
Foreign References:
| CN115607563A | 2023-01-17 | |||
| CN111838681A | 2020-10-30 | |||
| CN111700870A | 2020-09-25 |
Other References:
SUN SHAN, ZHANG XUEDI, LI JIAXUAN, LI YU, ZHOU CHENGFU, XIANG SIYUAN, TAN MINGQIAN: "Preparation and evaluation of ovalbumin-fucoidan nanoparticles for nicotinamide mononucleotide encapsulation with enhanced stability and anti-aging activity", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 418, 1 August 2023 (2023-08-01), NL , pages 135982, XP093140644, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2023.135982
FENG JIN, XU HUIQING, ZHANG LIXIA, WANG HUA, LIU SONGBAI, LIU YUJIAO, HOU WANWEI, LI CHUNYANG: "Development of Nanocomplexes for Curcumin Vehiculization Using Ovalbumin and Sodium Alginate as Building Blocks: Improved Stability, Bioaccessibility, and Antioxidant Activity", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 67, no. 1, 9 January 2019 (2019-01-09), US , pages 379 - 390, XP093140646, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b02567
FENG JIN, XU HUIQING, ZHANG LIXIA, WANG HUA, LIU SONGBAI, LIU YUJIAO, HOU WANWEI, LI CHUNYANG: "Development of Nanocomplexes for Curcumin Vehiculization Using Ovalbumin and Sodium Alginate as Building Blocks: Improved Stability, Bioaccessibility, and Antioxidant Activity", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 67, no. 1, 9 January 2019 (2019-01-09), US , pages 379 - 390, XP093140646, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b02567
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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