Title:
NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/202274
Kind Code:
A1
Abstract:
Disclosed are a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to nicotinyl alcohol ether derivative represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
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Inventors:
FENG ZHIQIANG (CN)
CHEN XIAOGUANG (CN)
YANG YANG (CN)
ZHENG YI (CN)
LAI FANGFANG (CN)
JI MING (CN)
ZHOU CHUAN (CN)
ZHANG LIJING (CN)
WANG KE (CN)
XUE NINA (CN)
LI LING (CN)
CHEN XIAOGUANG (CN)
YANG YANG (CN)
ZHENG YI (CN)
LAI FANGFANG (CN)
JI MING (CN)
ZHOU CHUAN (CN)
ZHANG LIJING (CN)
WANG KE (CN)
XUE NINA (CN)
LI LING (CN)
Application Number:
PCT/CN2017/085418
Publication Date:
November 30, 2017
Filing Date:
May 23, 2017
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07D405/14; A61K31/40; A61K31/44; A61P31/04; A61P31/12; A61P35/00; A61P37/02; C07D207/16
Domestic Patent References:
| WO2015160641A2 | 2015-10-22 | |||
| WO2013126428A1 | 2013-08-29 |
Foreign References:
| CN103787902A | 2014-05-14 |
Other References:
See also references of EP 3466944A4
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