Title:
NITROGEN-CONTAINING FUSED THREE RING PRMT5 INHIBITOR, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027370
Kind Code:
A1
Abstract:
A PRMT5 inhibitor having a structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, the use thereof as a PRMT5 inhibitor, and the use thereof in the treatment and/or prevention of PRMT5-mediated diseases.
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Inventors:
DENG HAIBING (CN)
LIU ZHAOMIN (CN)
YANG FEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
LIU ZHAOMIN (CN)
YANG FEI (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2023/102507
Publication Date:
February 08, 2024
Filing Date:
June 26, 2023
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D487/04; A61K31/4353; A61P35/00
Domestic Patent References:
WO2022132914A1 | 2022-06-23 | |||
WO2022115377A1 | 2022-06-02 |
Foreign References:
US20200039984A1 | 2020-02-06 | |||
US20040192698A1 | 2004-09-30 | |||
US6235740B1 | 2001-05-22 | |||
CN110621333A | 2019-12-27 | |||
CN102388044A | 2012-03-21 |
Other References:
LI, BEI ET AL.: "Hit-to-Lead Optimization and Kinase Selectivity of Imidazo[1,2-α]quinoxalin-4-amine Derived JNK1 Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 18, 8 July 2013 (2013-07-08), XP028694503, DOI: 10.1016/j.bmcl.2013.06.087
SHYLAJA RAMANATHAN, KAVITHA RENGARAJAN, MEGANATHAN CHANDRASEKARAN: "Atom Based 3D-QSAR, Molecular Docking and Density Functional Theory Approaches to Identify Novel JNK-1 Inhibitor", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, BENTHAM SCIENCE PUBLISHERS, NL, vol. 19, 1 January 2016 (2016-01-01), NL , pages 771 - 797, XP093136782, ISSN: 1386-2073, DOI: 10.2174/13862073196661609
DATABASE Registry CAS; 21 April 2021 (2021-04-21), ANONYMOUS : "Imidazo[1,2-a]quinoxaline-8-car boxamide, N-[1-(4-fluorophenyl)-1-met hylethyl]-4-[(trans-4-hydrox ycyclohexyl)amino]-", XP093136810, retrieved from STN Database accession no. 2636024-19-4
DATABASE Registry CAS; 7 December 2011 (2011-12-07), ANONYMOUS : "[1,2,4]Triazolo[4,3-a]quinoxaline -8-carboxamide, N-(cyclopropylmethyl)-1,2-d ihydro-N-methyl-4-[(1-meth ylethyl)amino]-1-oxo- ", XP093136812, retrieved from STN Database accession no. 1350018-39-1
DATABASE Registry CAS; 16 December 2022 (2022-12-16), ANONYMOUS : "Imidazo[1,2-a]quinoxaline-8-car boxamide, 4-[(trans-4-hydroxycyclohe xyl)amino]-N-[(2-methylcycl opropyl)methyl]-", XP093136814, retrieved from STN Database accession no. 2870614-22-3
SHYLAJA RAMANATHAN, KAVITHA RENGARAJAN, MEGANATHAN CHANDRASEKARAN: "Atom Based 3D-QSAR, Molecular Docking and Density Functional Theory Approaches to Identify Novel JNK-1 Inhibitor", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, BENTHAM SCIENCE PUBLISHERS, NL, vol. 19, 1 January 2016 (2016-01-01), NL , pages 771 - 797, XP093136782, ISSN: 1386-2073, DOI: 10.2174/13862073196661609
DATABASE Registry CAS; 21 April 2021 (2021-04-21), ANONYMOUS : "Imidazo[1,2-a]quinoxaline-8-car boxamide, N-[1-(4-fluorophenyl)-1-met hylethyl]-4-[(trans-4-hydrox ycyclohexyl)amino]-", XP093136810, retrieved from STN Database accession no. 2636024-19-4
DATABASE Registry CAS; 7 December 2011 (2011-12-07), ANONYMOUS : "[1,2,4]Triazolo[4,3-a]quinoxaline -8-carboxamide, N-(cyclopropylmethyl)-1,2-d ihydro-N-methyl-4-[(1-meth ylethyl)amino]-1-oxo- ", XP093136812, retrieved from STN Database accession no. 1350018-39-1
DATABASE Registry CAS; 16 December 2022 (2022-12-16), ANONYMOUS : "Imidazo[1,2-a]quinoxaline-8-car boxamide, 4-[(trans-4-hydroxycyclohe xyl)amino]-N-[(2-methylcycl opropyl)methyl]-", XP093136814, retrieved from STN Database accession no. 2870614-22-3
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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