Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/174378
Kind Code:
A1
Abstract:
The present invention relates to a nitrogen-containing heterocyclic compound. Specifically, provided in the present invention is a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof. The compound of the present invention has a good precise treatment effect on tumors with low expression, no expression, low activity or no activity of mitochondrial permeability transition pores and/or low expression, no expression, low activity or no activity of peptidylprolyl isomerase F.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
Application Number:
PCT/CN2023/081964
Publication Date:
September 21, 2023
Filing Date:
March 16, 2023
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
International Classes:
C07D455/03; A61K31/4375; A61P35/00
Domestic Patent References:
| WO2018068769A1 | 2018-04-19 |
Foreign References:
| CN114644626A | 2022-06-21 | |||
| CN102421774A | 2012-04-18 | |||
| CN101541977A | 2009-09-23 | |||
| CN113350329A | 2021-09-07 | |||
| CN104211709A | 2014-12-17 | |||
| US20100120810A1 | 2010-05-13 | |||
| CN107141284A | 2017-09-08 | |||
| CN110372688A | 2019-10-25 | |||
| JPS5070397A | 1975-06-11 |
Other References:
PING QIAN, YANG XIU-WEI: "Alkaloids from Zuojin Formula and their cytotoxicities against proliferation of cancer cells", CHINESE TRADITIONAL AND HERBAL DRUGS, TAINJIN ZHONGCAOYAO ZAZAHISHE, CN, vol. 45, no. 1, 12 January 2014 (2014-01-12), CN , pages 8 - 15, XP093091792, ISSN: 0253-2670, DOI: 10.7501/j.issn.0253-2670.2014.01.002
DATABASE Registry 12 May 2012 (2012-05-12), ANONYMOUS: "4H-Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine, 4-hexyl-6,7-dihydro- (CA INDEX NAME)", XP093091793, retrieved from STNext Database accession no. 1374744-39-4
TANG XIAONAN, LI XIANG, WANG YUFEI, ZHANG ZHIHUI, DENG ANJUN, WANG WENJIE, ZHANG HAIJING, QIN HAILIN, WU LIANQIU: "Butyric Acid Increases the Therapeutic Effect of EHLJ7 on Ulcerative Colitis by Inhibiting JAK2/STAT3/SOCS1 Signaling Pathway", FRONTIERS IN PHARMACOLOGY, vol. 10, 22 January 2020 (2020-01-22), pages 1553, XP093091815, DOI: 10.3389/fphar.2019.01553
DAI BINGLING, MA YUJIAO, WANG WENJIE, ZHAN YINGZHUAN, ZHANG DONGDONG, LIU RUI, ZHANG YANMIN: "Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI‐H460 cells by repressing MAP kinase pathways and inflammatory mediators", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 21, no. 10, 1 October 2017 (2017-10-01), RO , pages 2573 - 2585, XP093091817, ISSN: 1582-1838, DOI: 10.1111/jcmm.13178
DATABASE Registry 12 May 2012 (2012-05-12), ANONYMOUS: "4H-Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine, 4-hexyl-6,7-dihydro- (CA INDEX NAME)", XP093091793, retrieved from STNext Database accession no. 1374744-39-4
TANG XIAONAN, LI XIANG, WANG YUFEI, ZHANG ZHIHUI, DENG ANJUN, WANG WENJIE, ZHANG HAIJING, QIN HAILIN, WU LIANQIU: "Butyric Acid Increases the Therapeutic Effect of EHLJ7 on Ulcerative Colitis by Inhibiting JAK2/STAT3/SOCS1 Signaling Pathway", FRONTIERS IN PHARMACOLOGY, vol. 10, 22 January 2020 (2020-01-22), pages 1553, XP093091815, DOI: 10.3389/fphar.2019.01553
DAI BINGLING, MA YUJIAO, WANG WENJIE, ZHAN YINGZHUAN, ZHANG DONGDONG, LIU RUI, ZHANG YANMIN: "Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI‐H460 cells by repressing MAP kinase pathways and inflammatory mediators", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 21, no. 10, 1 October 2017 (2017-10-01), RO , pages 2573 - 2585, XP093091817, ISSN: 1582-1838, DOI: 10.1111/jcmm.13178
Attorney, Agent or Firm:
PANCHINA IP LAW OFFICE et al. (CN)
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