Title:
TETRACYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/174377
Kind Code:
A1
Abstract:
The present invention relates to a tetracyclic compound and a use thereof. Specifically, the present invention provides a use of a compound of formula I, or an optical isomer, a racemate, a solvate, a pharmaceutically acceptable salt, or a deuterated compound thereof in the preparation of a composition or a formulation for preventing and/or treating tumors. The compound of the present invention has an excellent precise treatment effect on tumors with low or no expression and low or no activity of mitochondrial membrane permeability pores, low or no expression and low or no activity of recombinant peptidylprolyl isomerase F, low or no expression of NNMT gene, high expression of DNA methylases, high expression of UHRF1, a high methylation level at a nucleotide site of the NNMT gene, and/or a high methylation level at a DNA CpG site of a NNMT gene region.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
MA WENJIANG (CN)
PEI GANG (CN)
XIA PENG (CN)
Application Number:
PCT/CN2023/081936
Publication Date:
September 21, 2023
Filing Date:
March 16, 2023
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
International Classes:
C07D455/03; A61K31/4375; A61P35/00
Domestic Patent References:
| WO2022063311A1 | 2022-03-31 | |||
| WO2022063311A1 | 2022-03-31 | |||
| WO2022095972A1 | 2022-05-12 |
Foreign References:
| CN113599380A | 2021-11-05 | |||
| CN108997332A | 2018-12-14 | |||
| US20100120810A1 | 2010-05-13 | |||
| CN113350329A | 2021-09-07 | |||
| CN102127593A | 2011-07-20 | |||
| CN104211697A | 2014-12-17 | |||
| CN101153039A | 2008-04-02 |
Other References:
ZHANG YAN, ZHANG LIANG, ZHOU YIMING, ET AL : "Study on Pharmacological Action Mechanism of Berberine Chloride by Genome-wide Expression Profiling of Saccharomyces cerevisiae", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE, vol. 23, no. 1, 31 December 2003 (2003-12-31), pages 48 - 53, XP055928796
Attorney, Agent or Firm:
PANCHINA IP LAW OFFICE (CN)
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