Title:
NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/037716
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, R1 is an optionally substituted C1-4 alkyl, n is an integer of 1 to 4, R2 is an optionally substituted C1-4 alkyl or hydrogen atom, R3 is an optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d are the same or different and each is an optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom, or the like, and A is an optionally substituted C6-14 aryl or optionally substituted 5-member to 11-member heteroaryl.]
Inventors:
FUSANO AKIRA (JP)
KOBAYASHI TOMONORI (JP)
SAITO YASUHIRO (JP)
KANAI TOSHIO (JP)
KOBAYASHI TOMONORI (JP)
SAITO YASUHIRO (JP)
KANAI TOSHIO (JP)
Application Number:
PCT/JP2014/074283
Publication Date:
March 19, 2015
Filing Date:
September 12, 2014
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07D207/16; A61K31/40; A61K31/445; A61K31/453; A61K31/4535; A61K31/4545; A61P1/04; A61P9/10; A61P9/14; A61P11/06; A61P13/08; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/08; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D211/60; C07D401/12; C07D405/12; C07D409/12
Domestic Patent References:
| WO2010059922A1 | 2010-05-27 | |||
| WO2010059922A1 | 2010-05-27 | |||
| WO1997043278A1 | 1997-11-20 | |||
| WO2011047165A1 | 2011-04-21 | |||
| WO1999019301A1 | 1999-04-22 | |||
| WO2011026917A1 | 2011-03-10 | |||
| WO2006091697A1 | 2006-08-31 | |||
| WO2010118207A1 | 2010-10-14 | |||
| WO2011026904A1 | 2011-03-10 | |||
| WO2012036997A1 | 2012-03-22 | |||
| WO2004058727A1 | 2004-07-15 |
Other References:
DATABASE REGISTRY [online] 21 March 2010 (2010-03-21), "3-PIPERIDINECARBOXAMIDE, 1-(CYCLOPROPYLMETHYL)-5-(4-ETHYLPHENYL)-N-(1- PHENYLETHYL)- (CA INDEX NAME)", XP055327938, accession no. STN Database accession no. 1212064-14-6
DATABASE REGISTRY [online] 21 March 2010 (2010-03-21), "3-PIPERIDINECARBOXAMIDE, 5-(4-ETHYLPHENYL)-N-(1-PHENYLETHYL)-1-PROPYL- (CA INDEX NAME)", XP055327939, accession no. STN Database accession no. 1212329-68-4
DATABASE REGISTRY [online] 24 September 2010 (2010-09-24), "3-PIPERIDINECARBOXAMIDE, N-[1-(2,4-DIMETHYLPHENYL)ETHYL]-1-METHYL- (CA INDEX NAME)", XP055327942, accession no. STN Database accession no. 1242816-21-2
DATABASE REGISTRY [online] 26 September 2010 (2010-09-26), "3-PIPERIDINECARBOXAMIDE, 1-METHYL-N-[1-[4-(1-PYRROLIDINYL)PHENYL]ETHYL]- (CA INDEX NAME)", XP055327984, accession no. STN Database accession no. 1242830-57-4
DATABASE REGISTRY [online] 26 September 2010 (2010-09-26), "3-PIPERIDINECARBOXAMIDE, 1-METHYL-N-[1-[4-(METHYLSULFONYL)PHENYL]PROPYL]- (CA INDEX NAME)", XP055328000, accession no. STN Database accession no. 1242835-30-8
DATABASE REGISTRY [online] 18 December 2013 (2013-12-18), "3-PIPERIDINECARBOXAMIDE, N-[1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-METHYLETHYL]-1-(1-METHYLETHYL)- (CA INDEX NAME)", XP055328012, accession no. STN Database accession no. 1497636-62-0
DATABASE REGISTRY [online] 3 January 2014 (2014-01-03), "4-THIAZOLECARBOXYLIC ACID, 2-[1-[[(1-METHYL-3- PYRROLIDINYL)CARBONYL]AMINO]ETHYL]- (CA INDEX NAME)", XP055328052, accession no. STN Database accession no. 1510323-50-8
COSTAKIS E. ET AL.: "Synthesis and preliminary pharmacological study of some a-phenylalkylamides and a-phenylalkylamines", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 36, no. 7-8, 1978, pages 349 - 360, XP008182993
See also references of EP 3045448A4
TETRAHEDRON LETTERS, vol. 28, 1987, pages 6513 - 6516
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 19, 2011, pages 5238 - 5246
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 1836 - 1846
TETRAHEDRON, vol. 63, 2007, pages 10486 - 10496
JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 942 - 946
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 133, 2011, pages 2878 - 2880
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 17, 2009, pages 5639 - 5647
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, 1999, pages 363 - 380
THEODORA W. GREENE; PETER G M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
"Series of Experimental Chemistry", vol. 1, MARUZEN CO., LTD.
DATABASE REGISTRY [online] 21 March 2010 (2010-03-21), "3-PIPERIDINECARBOXAMIDE, 5-(4-ETHYLPHENYL)-N-(1-PHENYLETHYL)-1-PROPYL- (CA INDEX NAME)", XP055327939, accession no. STN Database accession no. 1212329-68-4
DATABASE REGISTRY [online] 24 September 2010 (2010-09-24), "3-PIPERIDINECARBOXAMIDE, N-[1-(2,4-DIMETHYLPHENYL)ETHYL]-1-METHYL- (CA INDEX NAME)", XP055327942, accession no. STN Database accession no. 1242816-21-2
DATABASE REGISTRY [online] 26 September 2010 (2010-09-26), "3-PIPERIDINECARBOXAMIDE, 1-METHYL-N-[1-[4-(1-PYRROLIDINYL)PHENYL]ETHYL]- (CA INDEX NAME)", XP055327984, accession no. STN Database accession no. 1242830-57-4
DATABASE REGISTRY [online] 26 September 2010 (2010-09-26), "3-PIPERIDINECARBOXAMIDE, 1-METHYL-N-[1-[4-(METHYLSULFONYL)PHENYL]PROPYL]- (CA INDEX NAME)", XP055328000, accession no. STN Database accession no. 1242835-30-8
DATABASE REGISTRY [online] 18 December 2013 (2013-12-18), "3-PIPERIDINECARBOXAMIDE, N-[1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-METHYLETHYL]-1-(1-METHYLETHYL)- (CA INDEX NAME)", XP055328012, accession no. STN Database accession no. 1497636-62-0
DATABASE REGISTRY [online] 3 January 2014 (2014-01-03), "4-THIAZOLECARBOXYLIC ACID, 2-[1-[[(1-METHYL-3- PYRROLIDINYL)CARBONYL]AMINO]ETHYL]- (CA INDEX NAME)", XP055328052, accession no. STN Database accession no. 1510323-50-8
COSTAKIS E. ET AL.: "Synthesis and preliminary pharmacological study of some a-phenylalkylamides and a-phenylalkylamines", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 36, no. 7-8, 1978, pages 349 - 360, XP008182993
See also references of EP 3045448A4
TETRAHEDRON LETTERS, vol. 28, 1987, pages 6513 - 6516
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 19, 2011, pages 5238 - 5246
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 1836 - 1846
TETRAHEDRON, vol. 63, 2007, pages 10486 - 10496
JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 942 - 946
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 133, 2011, pages 2878 - 2880
BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 17, 2009, pages 5639 - 5647
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, 1999, pages 363 - 380
THEODORA W. GREENE; PETER G M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
"Series of Experimental Chemistry", vol. 1, MARUZEN CO., LTD.
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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