Title:
NON-HUMAN ORGANISM CAPABLE OF SPECIFICALLY ELIMINATING SPECIFIED CELLS
Document Type and Number:
WIPO Patent Application WO/2024/042886
Kind Code:
A1
Abstract:
Provided are: a combination of a DNA construct comprising a first site-specific recombinase gene disposed so as to be capable of acting on a promoter of a first gene specific to a specified cell through a DNA construct comprising an n-th site-specific recombinase gene disposed so as to be capable of acting on a promoter of an n-th gene specific to said cell and a DNA construct comprising a killing gene disposed so as to be capable of acting on a constitutive promoter and in which each of transcriptional termination sequences disposed between sequences recognized and excised by the first through n-th site-specific recombinases is disposed between the constitutive promoter and the killing gene; a cell into which said combination has been introduced; and a non-human organism comprising said cell.
Inventors:
YAMAMOTO MASAHIRO (JP)
Application Number:
PCT/JP2023/025274
Publication Date:
February 29, 2024
Filing Date:
July 07, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12N15/11; A01K67/027; A61K35/12; A61K48/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/52
Foreign References:
| US20170183654A1 | 2017-06-29 |
Other References:
WANG HAIXIAO, HE LINGJUAN, LI YAN, PU WENJUAN, ZHANG SHAOHUA, HAN XIMENG, LUI KATHY O., ZHOU BIN: "Dual Cre and Dre recombinases mediate synchronized lineage tracing and cell subset ablation in vivo", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 298, no. 6, 1 June 2022 (2022-06-01), US , pages 101965, XP093142341, ISSN: 0021-9258, DOI: 10.1016/j.jbc.2022.101965
NELSON RYAN W., MCLACHLAN JAMES B., KURTZ JONATHAN R., JENKINS MARC K.: "CD4+ T Cell Persistence and Function after Infection Are Maintained by Low-Level Peptide:MHC Class II Presentation", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 190, no. 6, 15 March 2013 (2013-03-15), US , pages 2828 - 2834, XP093142342, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1202183
CHUNWEI DONG, GAO WANG, JIN BO, JIANG QING: "Advances in Cathode Materials for High-Performance Lithium-Sulfur Batteries", 31 August 2018 (2018-08-31), XP055528980, [retrieved on 20181130], DOI: 10.1016/j.isci
OKAMOTO MASAAKI, SASAI MIWA, KURATANI AYUMI, OKUZAKI DAISUKE, ARAI MASAYA, WING JAMES B., SAKAGUCHI SHIMON, YAMAMOTO MASAHIRO: "A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity", CELL REPORTS, ELSEVIER INC, US, vol. 42, no. 7, 1 July 2023 (2023-07-01), US , pages 112813, XP093142339, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2023.112813
NELSON RYAN W., MCLACHLAN JAMES B., KURTZ JONATHAN R., JENKINS MARC K.: "CD4+ T Cell Persistence and Function after Infection Are Maintained by Low-Level Peptide:MHC Class II Presentation", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 190, no. 6, 15 March 2013 (2013-03-15), US , pages 2828 - 2834, XP093142342, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1202183
CHUNWEI DONG, GAO WANG, JIN BO, JIANG QING: "Advances in Cathode Materials for High-Performance Lithium-Sulfur Batteries", 31 August 2018 (2018-08-31), XP055528980, [retrieved on 20181130], DOI: 10.1016/j.isci
OKAMOTO MASAAKI, SASAI MIWA, KURATANI AYUMI, OKUZAKI DAISUKE, ARAI MASAYA, WING JAMES B., SAKAGUCHI SHIMON, YAMAMOTO MASAHIRO: "A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity", CELL REPORTS, ELSEVIER INC, US, vol. 42, no. 7, 1 July 2023 (2023-07-01), US , pages 112813, XP093142339, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2023.112813
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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