Title:
NON-INVASIVE DIAGNOSTIC IMAGING AGENT FOR HEART DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/213247
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a technique for detecting a lesion of a heart disease in a non-invasive manner. The present invention provides a non-invasive diagnostic imaging agent for a heart disease, which contains a radioactive labeling compound capable of binding to an aldosterone synthase or a salt thereof as an active ingredient.
Inventors:
MAYA YOSHIFUMI (JP)
Application Number:
PCT/JP2017/021442
Publication Date:
December 14, 2017
Filing Date:
June 09, 2017
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
A61K51/04; A61K49/00; A61K49/04
Domestic Patent References:
| WO2015199205A1 | 2015-12-30 |
Foreign References:
| JP2014526539A | 2014-10-06 | |||
| JP2013512271A | 2013-04-11 |
Other References:
ABE TSUTOMU ET AL.: "A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism", J. CLIN. ENDOCRINOL. METAB., vol. 101, no. 3, March 2016 (2016-03-01), pages 1008 - 1015, XP055456963, ISSN: 0021-972X
VEERAVEEDU T. PUNNIYAKOTI ET AL.: "Comparative effects of torasemide and furosemide in rats with heart failure", BIOCHEMICAL PHARMACOLOGY, vol. 75, no. 3, 2008, pages 649 - 659, XP022418012, ISSN: 0006-2952
VEERAVEEDU T. PUNNIYAKOTI ET AL.: "Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 581, no. 1-2, 2008, pages 121 - 131, XP022442578, ISSN: 0014-2999
KATADA JUN ET AL.: "Persistent Cardiac Aldosterone Synthesis in Angiotensin II Type 1A Receptor-Knockout Mice After Myocardial Infarction", CIRCULATION, vol. 111, no. 17, 2005, pages 2157 - 2164, XP055456972, ISSN: 0009-7322
SATOH MAMORU ET AL.: "Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart", CLINICAL SCIENCE, vol. 102, 2002, pages 381 - 386, XP055562970, ISSN: 0143-5221
See also references of EP 3470091A4
VEERAVEEDU T. PUNNIYAKOTI ET AL.: "Comparative effects of torasemide and furosemide in rats with heart failure", BIOCHEMICAL PHARMACOLOGY, vol. 75, no. 3, 2008, pages 649 - 659, XP022418012, ISSN: 0006-2952
VEERAVEEDU T. PUNNIYAKOTI ET AL.: "Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 581, no. 1-2, 2008, pages 121 - 131, XP022442578, ISSN: 0014-2999
KATADA JUN ET AL.: "Persistent Cardiac Aldosterone Synthesis in Angiotensin II Type 1A Receptor-Knockout Mice After Myocardial Infarction", CIRCULATION, vol. 111, no. 17, 2005, pages 2157 - 2164, XP055456972, ISSN: 0009-7322
SATOH MAMORU ET AL.: "Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart", CLINICAL SCIENCE, vol. 102, 2002, pages 381 - 386, XP055562970, ISSN: 0143-5221
See also references of EP 3470091A4
Attorney, Agent or Firm:
IDE Masatake (JP)
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