NOVEL 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE VARIANT AND METHOD FOR PRODUCING L-VALINE USING SAME

Title:

NOVEL 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE VARIANT AND METHOD FOR PRODUCING L-VALINE USING SAME

Document Type and Number:

WIPO Patent Application WO/2022/163924

Kind Code:

A1

Abstract:

The present application relates to a novel 5,10-methylenetetrahydrofolate reductase variant, Corynebacterium stationis strain comprising the variant, and a method for producing L-valine using the strain.

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Inventors:

BAE JEE YEON (KR)
KIM SEON HYE (KR)
YOON BYOUNG HOON (KR)
PARK GOUN (KR)
KIM HYO JIN (KR)
KIM HYUNG JOON (KR)

Application Number:

PCT/KR2021/004518

Publication Date:

August 04, 2022

Filing Date:

April 09, 2021

Export Citation:

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Assignee:

CJ CHEILJEDANG CORP (KR)

International Classes:

C12N9/06; C12N15/77; C12P13/08

Foreign References:

KR101117022B1	2012-03-16
KR20060039992A	2006-05-10
KR20160148006A	2016-12-23
US20020049305A1	2002-04-25
US8465962B2	2013-06-18
US7662943B2	2010-02-16
US10584338B2	2020-03-10
US10273491B2	2019-04-30

Other References:

DATABASE Protein NCBI; 17 June 2017 (2017-06-17), ANONYMOUS : "5,10-methylenetetrahydrofolate reductase [Corynebacterium glutamicum]", XP055954899, Database accession no. BAV23789
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS GENET, vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
ATSCHUL, S. F. ET AL., J MOLEC BIOL, vol. 215, 1990, pages 403
GENE, vol. 145, 1994, pages 69 - 73
"SIAM J Applied Math", vol. 48, 1988, pages: 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, no. 443, 1970
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"Atlas Of Protein Sequence And Structure", 1979, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, pages: 353 - 358
"NCBI", Database accession no. WP_003863792.1
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS GENET., vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
F.M. AUSUBEL ET AL.: "Molecular Cloning, A Laboratory Manual", vol. 50-51, 1989, COLD SPRING HARBOR LABORATORY PRESS, pages: 7 - 8
NAKASHIMA N ET AL.: "Bacterial cellular engineering by genome editing and gene silencing", INT J MOL SCI, vol. 15, no. 2, 2014, pages 2773 - 2793, XP055376889, DOI: 10.3390/ijms15022773
SAMBROOK ET AL., MOLECULAR CLONING, 2012
WEINTRAUB, H ET AL.: "Antisense-RNA as a molecular tool for genetic analysis", REVIEWS-TRENDS IN GENETICS, vol. 1, no. 1, 1986
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
See also references of EP 4056692A4

Attorney, Agent or Firm:

YOU ME PATENT AND LAW FIRM (KR)

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