Title:
NOVEL ANTIVIRAL MACROCYCLE DERIVATIVES AND METAL COMPLEXES, INCORPORATING BRIDGED MACROCYCLES
Document Type and Number:
WIPO Patent Application WO2005121109
Kind Code:
A3
Abstract:
A compound of Formulae (1), (2) or (3), A
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Inventors:
ARCHIBALD STEPHEN JAMES (GB)
LEWIS ELIZABETH AMIE (GB)
HUBIN TIMOTHY J (US)
LEWIS ELIZABETH AMIE (GB)
HUBIN TIMOTHY J (US)
Application Number:
PCT/GB2005/002297
Publication Date:
March 09, 2006
Filing Date:
June 10, 2005
Export Citation:
Assignee:
UNIV HULL (GB)
ARCHIBALD STEPHEN JAMES (GB)
LEWIS ELIZABETH AMIE (GB)
HUBIN TIMOTHY J (US)
ARCHIBALD STEPHEN JAMES (GB)
LEWIS ELIZABETH AMIE (GB)
HUBIN TIMOTHY J (US)
International Classes:
C07D487/08; A61K31/395; C07D257/00
Domestic Patent References:
| WO1998039098A1 | 1998-09-11 |
Foreign References:
| US5047527A | 1991-09-10 | |||
| US5997353A | 1999-12-07 | |||
| JP2000239272A | 2000-09-05 |
Other References:
LARS OLE GERLACH, RENATO T. SKERLJ, GARY J. BRIDGER, THUE W. SCHWARTZ: "Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor", J. BIOL. CHEM., vol. 276, no. 17, 2001, pages 14153 - 14160, XP002357019
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfure am Main, DE; 1995, XP002357028, Database accession no. 7211737 (BRN)
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfurt am Main, DE; 2003, XP002357029, Database accession no. 9349922 (BRN)
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfurt am Main, DE; 2000, XP002357030, Database accession no. 8571265 (BRN)
ESTE J A ET AL: "ACTIVITY OF DIFFERENT BICYCLAM DERIVATIVES AGAINST HUMAN IMMUNODEFICIENCY VIRUS DEPENDS ON THEIR INTERACTION WITH THE CXCR4 CHEMOKINE RECEPTOR", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 55, no. 1, 1999, pages 67 - 73, XP008038631, ISSN: 0026-895X
H.E.EGBERINK, E. DE CLERCQ, A.L.W. VAN VLIET, J. BALZARINI ET AL.: "Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication", JOURNAL OF VIROLOGY, vol. 1999, 1999, pages 6346 - 6352, XP002357020
E.H. WONG, G. R. WEISMAN, D. C. HILL, D.P. REED ET AL.: "Synthesis and characterization of cross-bridged cyclams and pendant-armed derivatives and structural studies of their copper(II) complexes", J. AM. CHEM. SOC., vol. 122, 2000, pages 10561 - 10572, XP002357021
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfure am Main, DE; 1995, XP002357028, Database accession no. 7211737 (BRN)
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfurt am Main, DE; 2003, XP002357029, Database accession no. 9349922 (BRN)
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Förderung der Wissenschaften, Frankfurt am Main, DE; 2000, XP002357030, Database accession no. 8571265 (BRN)
ESTE J A ET AL: "ACTIVITY OF DIFFERENT BICYCLAM DERIVATIVES AGAINST HUMAN IMMUNODEFICIENCY VIRUS DEPENDS ON THEIR INTERACTION WITH THE CXCR4 CHEMOKINE RECEPTOR", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 55, no. 1, 1999, pages 67 - 73, XP008038631, ISSN: 0026-895X
H.E.EGBERINK, E. DE CLERCQ, A.L.W. VAN VLIET, J. BALZARINI ET AL.: "Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication", JOURNAL OF VIROLOGY, vol. 1999, 1999, pages 6346 - 6352, XP002357020
E.H. WONG, G. R. WEISMAN, D. C. HILL, D.P. REED ET AL.: "Synthesis and characterization of cross-bridged cyclams and pendant-armed derivatives and structural studies of their copper(II) complexes", J. AM. CHEM. SOC., vol. 122, 2000, pages 10561 - 10572, XP002357021
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