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Title:
NOVEL BENZOXATHIIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/049798
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent -CH-, a nitrogen atom or the like.]

Inventors:
SASAKI TAKAHIDE (JP)
SATO NAGAAKI (JP)
TAKAHASHI TOSHIYUKI (JP)
MIZUTANI TAKASHI (JP)
Application Number:
PCT/JP2006/321813
Publication Date:
May 03, 2007
Filing Date:
October 25, 2006
Export Citation:
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Assignee:
BANYU PHARMA CO LTD (JP)
SASAKI TAKAHIDE (JP)
SATO NAGAAKI (JP)
TAKAHASHI TOSHIYUKI (JP)
MIZUTANI TAKASHI (JP)
International Classes:
C07D327/06; A61K31/4025; A61K31/4365; A61K31/4535; A61K31/454; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P5/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/06; A61P25/00; A61P25/08; A61P25/16; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P43/00; C07D411/04; C07D411/12; C07D497/04
Domestic Patent References:
WO2003086388A12003-10-23
WO2003087073A12003-10-23
WO2002032377A22002-04-25
WO2003091239A12003-11-06
WO1996033159A11996-10-24
WO1998033765A11998-08-06
WO1998043636A11998-10-08
WO1998043635A11998-10-08
WO2001009120A12001-02-08
WO2001096330A22001-12-20
WO1998031227A11998-07-23
WO1998041519A11998-09-24
WO1998037061A11998-08-27
WO2000010967A12000-03-02
WO2000010968A22000-03-02
WO1997029079A11997-08-14
WO1999002499A11999-01-21
WO2001058869A22001-08-16
WO2002076949A12002-10-03
WO2001064632A12001-09-07
WO2001064633A12001-09-07
WO2001064634A12001-09-07
WO2003006007A12003-01-23
WO2003007887A22003-01-30
WO2001087355A12001-11-22
WO2002008250A22002-01-31
WO2002015905A12002-02-28
WO2001082925A12001-11-08
WO2001087834A12001-11-22
WO2002051809A12002-07-04
WO2002006245A12002-01-24
WO2002076929A12002-10-03
WO2002076947A12002-10-03
WO2002004433A22002-01-17
WO2002051809A12002-07-04
WO2002083134A12002-10-24
WO2002094799A22002-11-28
WO2003004027A12003-01-16
WO1996014307A11996-05-17
WO2001023387A22001-04-05
WO1999051600A11999-10-14
WO2001085690A12001-11-15
WO2001085098A22001-11-15
WO2001085173A12001-11-15
WO2001089528A12001-11-29
WO1997019682A11997-06-05
WO1997020820A11997-06-12
WO1997020821A11997-06-12
WO1997020822A11997-06-12
WO1997020823A21997-06-12
WO1998027063A11998-06-25
WO2001007409A12001-02-01
WO2001085714A12001-11-15
WO2001085730A12001-11-15
WO2000064880A12000-11-02
WO2000068197A12000-11-16
WO2000069849A12000-11-23
WO2001014376A12001-03-01
WO2001002379A12001-01-11
WO2001023388A22001-04-05
WO2001023389A22001-04-05
WO2001044201A12001-06-21
WO2001062737A22001-08-30
WO2001062738A12001-08-30
WO2002020488A22002-03-14
WO2002022592A22002-03-21
WO2002048152A22002-06-20
WO2002049648A12002-06-27
WO2002094789A12002-11-28
WO1996023513A11996-08-08
WO1996023514A11996-08-08
WO1996023515A11996-08-08
WO1996023516A11996-08-08
WO1996023517A11996-08-08
WO1996023518A11996-08-08
WO1996023519A11996-08-08
WO1996023520A11996-08-08
WO2001096302A12001-12-20
WO2001068609A12001-09-20
WO2002051232A22002-07-04
WO2002051838A12002-07-04
WO2003023561A22003-03-20
WO1994009134A21994-04-28
WO1998022128A11998-05-28
WO1999043813A11999-09-02
WO2001056592A12001-08-09
WO2002032888A12002-04-25
WO2002036596A22002-05-10
WO2002048124A22002-06-20
WO2002010169A12002-02-07
WO2001066548A12001-09-13
WO2002044152A12002-06-06
WO2002051844A12002-07-04
WO2002040456A12002-05-23
WO2002040457A12002-05-23
WO1999064002A11999-12-16
WO2000074679A12000-12-14
WO2001074844A22001-10-11
WO2001070708A12001-09-27
WO2001070337A12001-09-27
WO2001091752A12001-12-06
WO2002059095A12002-08-01
WO2002059107A12002-08-01
WO2002059108A12002-08-01
WO2002059117A12002-08-01
WO2002012166A22002-02-14
WO2002011715A22002-02-14
WO2002012178A12002-02-14
WO2002015909A12002-02-28
WO2002068387A22002-09-06
WO2002068388A22002-09-06
WO2002067869A22002-09-06
WO2003007949A12003-01-30
WO2003009847A12003-02-06
WO2001027068A12001-04-19
WO2001062341A22001-08-30
WO2001027060A12001-04-19
WO2001062341A22001-08-30
WO2001074782A12001-10-11
WO2002032897A12002-04-25
WO2002015845A22002-02-28
WO1999000123A11999-01-07
WO2001090091A12001-11-29
WO2001090090A12001-11-29
WO2001090092A12001-11-29
WO2003004498A12003-01-16
WO2003004496A12003-01-16
WO2002083128A12002-10-24
WO2002062764A12002-08-15
WO2003000250A12003-01-03
WO2003002530A22003-01-09
WO2003002531A22003-01-09
WO2003002553A22003-01-09
WO2003002593A22003-01-09
WO2003000180A22003-01-03
WO2003000181A22003-01-03
WO2001077094A12001-10-18
Foreign References:
JP2004511502A2004-04-15
JP2004511501A2004-04-15
JP2005529136A2005-09-29
US5532237A1996-07-02
US4973587A1990-11-27
US5013837A1991-05-07
US5081122A1992-01-14
US5112820A1992-05-12
US5292736A1994-03-08
US5624941A1997-04-29
US6028084A2000-02-22
EP0658546A11995-06-21
JP2001226269A2001-08-21
US6001836A1999-12-14
US6140354A2000-10-31
US6191160B12001-02-20
US6258837B12001-07-10
US6313298B12001-11-06
US6337332B12002-01-08
US6329395B12001-12-11
US6340683B12002-01-22
US6326375B12001-12-04
US6337332B12002-01-08
US6335345B12002-01-01
EP1010691A22000-06-21
EP1044970A12000-10-18
US5552524A1996-09-03
US5552523A1996-09-03
US5552522A1996-09-03
US5521283A1996-05-28
US5739106A1998-04-14
US6358951B12002-03-19
US20020049196A12002-04-25
US20020022637A12002-02-21
US3914250A1975-10-21
US4746680A1988-05-24
US4806570A1989-02-21
US5436272A1995-07-25
US20020006964A12002-01-17
US6365633B12002-04-02
US5705515A1998-01-06
US5451677A1995-09-19
JP2000256190A2000-09-19
EP1258476A12002-11-20
US4598089A1986-07-01
US4452813A1984-06-05
US5512565A1996-04-30
US5391571A1995-02-21
US5602151A1997-02-11
US4405644A1983-09-20
US4189438A1980-02-19
US4242453A1980-12-30
Other References:
CHEN H.Y. ET AL.: "Estrogen receptor ligands. Part 3: the SAR of dihydrobenzoxathiin SERMs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 10, 2004, pages 2551 - 2554, XP004841237
KIM S. ET AL.: "Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 9, 2004, pages 2171 - 2175, XP003012421
KIM S. ET AL.: "Estrogen receptor ligands. Part 4: The SAR of the syndihydrobenzoxathiin SERAMs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 11, 2004, pages 2741 - 2745, XP004841280
See also references of EP 1944301A4
LIFE SCIENCE, vol. 17, 1975, pages 503
JOURNAL OF COMPREHENSIVE NEUROLOGY, vol. 273, pages 283
PROGRESS IN NEUROBIOLOGY, vol. 63, 2001, pages 637
TRENDS IN PHARMACOLOGICAL SCIENCE, vol. 8, 1987, pages 24
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101
TRENDS IN PHARMACOLOGICAL SCIENCE, vol. 19, 1998, pages 177
NATURE, vol. 408, pages 860
BRAIN RESEARCH, vol. 523, 1990, pages 325
LIFE SCIENCE, vol. 48, 1991, pages 2397
BRAIN RESEARCH, vol. 793, 1998, pages 279
LIFE SCIENCE, vol. 69, 2001, pages 469
PHARMACOLOGY, BIOCHEMISTRY AND BEHAVIOR, vol. 68, 2001, pages 735
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 49, 1998, pages 191
BEHAVIORAL BRAIN RESEARCH, vol. 104, 1999, pages 147
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 234, 1993, pages 129
MITSUNOBU. 0.: "The use of diethyl azodicarboxylate and triphenylphosphine in synthesis and transformation of natural products", SYNTHESIS, vol. 1, 1981, pages 1 - 28
LAZEWSKA, D. ET AL., PHARMAZIE, vol. 56, 2001, pages 927 - 32
SASSE, A. ET AL., ARCH. PHARM. (WEINHEIM, vol. 334, 2001, pages 45 - 52
REIDEMEISTER, S. ET AL., PHARMAZIE, vol. 55, 2000, pages 83 - 6
SASSE, A. ET AL., J. MED. CHEM., vol. 43, 2000, pages 3335 - 43
NORMAN ET AL., J. MED. CHEM., vol. 43, 2000, pages 4288 - 4312
DEL MAR-GRASA, M. ET AL., OBESITY RESEARCH, vol. 9, 2001, pages 202 - 9
J. ORG. CHEM., vol. 52, 1987, pages 5466
J. ORG. CHEM., vol. 60, 1995, pages 1408
J. ORG. CHEM., vol. 54, 1989, pages 209
J. ORG. CHEM., vol. 33, 1968, pages 4426
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (1-13-12 Kudankit, Chiyoda-ku Tokyo 67, JP)
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