Title:
NOVEL BILE ACID CONVERTING MICROORGANISM AND PROCESS FOR PREPARING BILE ACID
Document Type and Number:
WIPO Patent Application WO/1997/036997
Kind Code:
A1
Abstract:
A microorganism having a capability of introducing a 7'beta'-hydroxyl group into a 7-unsubstituted bile acid, and a process for preparing a bile acid having a 7'beta'-hydroxyl group characterized by bringing the above microorganism into contact with a 7-unsubstituted bile acid to convert the acid to a bile acid having a 7'beta'-hydroxyl group. The process permits ursodeoxycholic acid useful as a cholagogue and intermediates therefor to be efficiently prepared.
Inventors:
OKAMURA AKIO (JP)
MATSUI HIROYUKI (JP)
MATSUI HIROYUKI (JP)
Application Number:
PCT/JP1997/000937
Publication Date:
October 09, 1997
Filing Date:
March 21, 1997
Export Citation:
Assignee:
TOKYO TANABE CO (JP)
OKAMURA AKIO (JP)
MATSUI HIROYUKI (JP)
OKAMURA AKIO (JP)
MATSUI HIROYUKI (JP)
International Classes:
C12P33/06; (IPC1-7): C12N1/14; C12P33/06
Other References:
J. LIPID RES., Vol. 22, (1981), CALSTROEM K. et al., "Microbial Synthesis of 1beta- and 15beta-hydroxylated Bile Acids", pages 1225-1234.
J. STEROID BIOCHEM., Vol. 14, (1981), JOANNOU G.E., "Identification of 15beta-Hydroxylated C21 Steroids in the Neo-Natal Period: the Role of 3alpha, 15beta, 17alpha-Trihydroxy-5beta-perinatal Diagnosis of Congenital Adrenal Hyperplasia (CAH) Due to a 21-Hydroxylase Deficiency", pages 901-912.
J. STEROID BIOCHEM., Vol. 14, (1981), JOANNOU G.E., "Identification of 15beta-Hydroxylated C21 Steroids in the Neo-Natal Period: the Role of 3alpha, 15beta, 17alpha-Trihydroxy-5beta-perinatal Diagnosis of Congenital Adrenal Hyperplasia (CAH) Due to a 21-Hydroxylase Deficiency", pages 901-912.
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