Title:
NOVEL COMPOUND, α-SYNUCLEIN AGGREGATE BINDER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/163033
Kind Code:
A1
Abstract:
Provided is a compound that has high binding selectivity to α-synuclein aggregates. The present invention relates to a compound represented by formula (I), (II) or (III), a pharmaceutically acceptable salt thereof, or a solvate of the compound or pharmaceutically acceptable salt.
Inventors:
HIGUCHI MAKOTO (JP)
ONO MAIKO (JP)
CHO MEIEI (JP)
TAKADO YUHEI (JP)
MATSUOKA KIWAMU (JP)
MIZUMA HIROSHI (JP)
YAMAMOTO TAKESHI (JP)
WAKABAYASHI TAKESHI (JP)
OHFUSA TOSHIYUKI (JP)
ONO MAIKO (JP)
CHO MEIEI (JP)
TAKADO YUHEI (JP)
MATSUOKA KIWAMU (JP)
MIZUMA HIROSHI (JP)
YAMAMOTO TAKESHI (JP)
WAKABAYASHI TAKESHI (JP)
OHFUSA TOSHIYUKI (JP)
Application Number:
PCT/JP2023/006432
Publication Date:
August 31, 2023
Filing Date:
February 22, 2023
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECH (JP)
EISAI R&D MAN CO LTD (JP)
ONO PHARMACEUTICAL CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
EISAI R&D MAN CO LTD (JP)
ONO PHARMACEUTICAL CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D417/06; A61K31/4427; A61K31/497; A61K51/00; A61P25/16; A61P25/28; A61P43/00
Domestic Patent References:
| WO2014097474A1 | 2014-06-26 | |||
| WO2020174963A1 | 2020-09-03 | |||
| WO2022045093A1 | 2022-03-03 |
Foreign References:
| JP2019512491A | 2019-05-16 |
Other References:
MIRANDA-AZPIAZU, PATRICIA ET AL.: "Identification and in vitro characterization of C05-01. a PBB3 derivative with improved affinity for alpha-synuclein", BRAIN RESEARCH, vol. 1749, no. 147131, 18 September 2020 (2020-09-18), pages 1 - 9, XP086327336, DOI: 10.1016/j.brainres.2020.147131
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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