Title:
NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES
Document Type and Number:
WIPO Patent Application WO2002079149
Kind Code:
A3
Abstract:
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof.The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents.The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.
More Like This:
Inventors:
KIMBALL SPENCER DAVID (US)
LOMBARDO LOUIS J (US)
RAWLINS DAVID B (US)
XIAO HAI-YUN (US)
SCHMIDT ROBERT JOSEPH (US)
WILLIAMS DAVID KENT (US)
LOMBARDO LOUIS J (US)
RAWLINS DAVID B (US)
XIAO HAI-YUN (US)
SCHMIDT ROBERT JOSEPH (US)
WILLIAMS DAVID KENT (US)
Application Number:
PCT/US2002/009497
Publication Date:
February 27, 2003
Filing Date:
March 26, 2002
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
KIMBALL SPENCER DAVID (US)
LOMBARDO LOUIS J (US)
RAWLINS DAVID B (US)
XIAO HAI-YUN (US)
SCHMIDT ROBERT JOSEPH (US)
WILLIAMS DAVID KENT (US)
KIMBALL SPENCER DAVID (US)
LOMBARDO LOUIS J (US)
RAWLINS DAVID B (US)
XIAO HAI-YUN (US)
SCHMIDT ROBERT JOSEPH (US)
WILLIAMS DAVID KENT (US)
International Classes:
A61K31/505; A61K31/506; A61K31/513; A61P9/14; A61P35/00; C07D211/90; C07D239/22; C07D239/36; C07D239/40; C07D239/42; C07D401/04; C07D401/10; C07D403/10; C07D403/12; C07D405/04; C07D409/04; C07D409/06; C07D409/10; C07D413/04; C07D413/10; C07D413/14; C07D417/04; (IPC1-7): C07D239/42; C07D409/04; C07D401/04; C07D403/12; A61K31/505; A61K31/506; A61P9/14
Other References:
CHEMICAL ABSTRACTS, vol. 100, no. 15, April 1984, Columbus, Ohio, US; abstract no. 121004W, TARASOVA O.A. ET AL.: "Tetrahydropyrimidine-2-thiones from tertiary acetylene alcohols and thiourea" page 588; XP002951993
CHEMICAL ABSTRACTS, vol. 100, no. 15, April 1984, Columbus, Ohio, US; abstract no. 121003V, RISE F. ET AL.: "Introduction of carbon substituents into pyrimidines by Grignard reagents" page 588; XP002951992
CHEMICAL ABSTRACTS, vol. 112, no. 17, April 1990, Columbus, Ohio, US; abstract no. 158194G, IBRAHIM N.S. ET AL.: "Reaction of isothiocyanates with active methylene reagent: A new approach for the synthesis of pyrazole, pyrimidine and pyrazolo(1,5-a)pyrimidine derivatives" column 714; XP002954729
KAPPE C.O. ET AL.: "Synthesis and reactions of Biginelli-compounds", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, no. 1, PARTR I, January 1989 (1989-01-01) - February 1989 (1989-02-01), pages 55 - 64, XP002952110
CHEMICAL ABSTRACTS, vol. 100, no. 15, April 1984, Columbus, Ohio, US; abstract no. 121003V, RISE F. ET AL.: "Introduction of carbon substituents into pyrimidines by Grignard reagents" page 588; XP002951992
CHEMICAL ABSTRACTS, vol. 112, no. 17, April 1990, Columbus, Ohio, US; abstract no. 158194G, IBRAHIM N.S. ET AL.: "Reaction of isothiocyanates with active methylene reagent: A new approach for the synthesis of pyrazole, pyrimidine and pyrazolo(1,5-a)pyrimidine derivatives" column 714; XP002954729
KAPPE C.O. ET AL.: "Synthesis and reactions of Biginelli-compounds", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, no. 1, PARTR I, January 1989 (1989-01-01) - February 1989 (1989-02-01), pages 55 - 64, XP002952110
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