Title:
NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/096567
Kind Code:
A1
Abstract:
A novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt; a polynucleotide encoding the same; and use thereof in, for example, drugs. This G protein-coupled receptor protein, its peptide fragment, its salt, and a polynucleotide encoding this receptor protein or its peptide fragment are usable in determining a ligand (an agonist), acquiring an antibody and an antiserum, constructing a recombinant receptor protein expression system, developing a receptor-bonded assay system and screening a candidate compound for a drug by using this expression system, designing a drug based on a comparison with a ligand receptor having a similar structure, a reagent for preparing a gene therapy probe and a PCR primer, constructing a transgenic animal, and a drug such as a preventive or a remedy.
Inventors:
MORIYA TAKEO (JP)
ITO TAKASHI (JP)
SHINTANI YASUSHI (JP)
MIYAJIMA NOBUYUKI (JP)
ITO TAKASHI (JP)
SHINTANI YASUSHI (JP)
MIYAJIMA NOBUYUKI (JP)
Application Number:
PCT/JP2001/005061
Publication Date:
December 20, 2001
Filing Date:
June 14, 2001
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MORIYA TAKEO (JP)
ITO TAKASHI (JP)
SHINTANI YASUSHI (JP)
MIYAJIMA NOBUYUKI (JP)
MORIYA TAKEO (JP)
ITO TAKASHI (JP)
SHINTANI YASUSHI (JP)
MIYAJIMA NOBUYUKI (JP)
International Classes:
A61P1/00; A61P3/10; A61P9/00; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07K14/705; C12N15/12; A61K48/00; (IPC1-7): C12N15/12; A61K38/00; A61K45/00; A61K48/00; A61P1/00; A61P3/10; A61P9/00; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07K14/705; C07K16/28; C12N1/21; C12P21/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Domestic Patent References:
| WO2000021999A1 | 2000-04-20 | |||
| WO2000022129A1 | 2000-04-20 |
Other References:
VANDERHAEGHEN P. ET AL.: "Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: Evidence for their wide distribution in the human genome", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 237, no. 2, 1997, pages 283 - 287, XP002945825
GERARD C.M. ET AL.: "Molecular cloning of a human cannabinoid receptor which is also expressed in testis", BIOCHEM. J., vol. 279, no. PT. 1, 1991, pages 129 - 134, XP002945826
MAHAIRAS G.G. ET AL.: "Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome", PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 9739 - 9744, XP002945827
GERARD C.M. ET AL.: "Molecular cloning of a human cannabinoid receptor which is also expressed in testis", BIOCHEM. J., vol. 279, no. PT. 1, 1991, pages 129 - 134, XP002945826
MAHAIRAS G.G. ET AL.: "Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome", PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 9739 - 9744, XP002945827
Attorney, Agent or Firm:
Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES (LTD. 17-85 Jusohonmachi 2-chom, Yodogawa-ku Osaka-shi Osaka, JP)
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