Title:
NOVEL HYDROXAMIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2000/069812
Kind Code:
A1
Abstract:
Compounds which are useful as drugs because of not only having a high metalloproteinase inhibitory activity but also being capable of remarkably improving the medicinal activities (for example, oral absorbability) and biological activities $i(in vivo); intermediates in the production thereof; and a process for producing the same. Compounds represented by general formula (I) wherein R?1¿, R?2¿, R?3¿, R?5¿, R?6¿, R?7¿ and R?8¿ represent each hydrogen, etc.; and R?4¿ represents alkyl, etc.; or salts thereof are useful as medicinal and/or veterinary compositions, in particular, metalloproteinase inhibitors inhibiting matrix metalloproteinases and/or tumor necrosis factor-$g(a) (TNF-$g(a)) convertase.
Inventors:
FUJISAWA TETSUNORI (JP)
ODAKE SHINJIRO (JP)
ITO HAJIME (JP)
YASUDA JUNKO (JP)
OHTANI MIWA (JP)
MORIKAWA TADANORI (JP)
ODAKE SHINJIRO (JP)
ITO HAJIME (JP)
YASUDA JUNKO (JP)
OHTANI MIWA (JP)
MORIKAWA TADANORI (JP)
Application Number:
PCT/JP2000/003166
Publication Date:
November 23, 2000
Filing Date:
May 17, 2000
Export Citation:
Assignee:
FUJI YAKUHIN KOGYO KK (JP)
FUJISAWA TETSUNORI (JP)
ODAKE SHINJIRO (JP)
ITO HAJIME (JP)
YASUDA JUNKO (JP)
OHTANI MIWA (JP)
MORIKAWA TADANORI (JP)
FUJISAWA TETSUNORI (JP)
ODAKE SHINJIRO (JP)
ITO HAJIME (JP)
YASUDA JUNKO (JP)
OHTANI MIWA (JP)
MORIKAWA TADANORI (JP)
International Classes:
A61K31/198; A61P43/00; C07C229/08; C07C233/47; C07C259/06; C07C279/14; (IPC1-7): C07C259/06; A61K31/198; A61K31/216; A61P43/00; C07C229/08; C07C231/02; C07C233/47
Domestic Patent References:
| WO1995022966A1 | 1995-08-31 | |||
| WO1994010990A1 | 1994-05-26 | |||
| WO1992009564A1 | 1992-06-11 |
Other References:
BOURDEL E. ET AL.: "New hydroxamate inhibitors of neurotensin-degrading enzymes", INT. J. PEPTIDE PROTEIN RES., vol. 48, no. 2, 1996, pages 148 - 155, XP002931252
Attorney, Agent or Firm:
Mizuno, Akinobu (Maruyama-cho Shibuya-ku Tokyo, JP)
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