Title:
NOVEL INFLAMMATORY DISEASE TREATMENT AGENT AND SCREENING METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2023/243689
Kind Code:
A1
Abstract:
The present invention provides: a sepsis and/or septic shock therapeutic agent containing, as an active ingredient, a compound that suppresses phosphorylation of threonine at position 749 of human STAT1; a method for screening a candidate compound for an active ingredient of a sepsis and/or septic shock therapeutic agent including a step for selecting a compound that suppresses phosphorylation of threonine at position 749 of human STAT1; a colitis treatment agent containing, as an active ingredient, a compound that promotes phosphorylation of threonine at position 749 of human STAT1; a method for screening a candidate compound for an active ingredient of a colitis treatment agent including a step for selecting a compound that promotes phosphorylation of threonine at position 749 of human STAT1; a systemic lupus erythematosus treatment agent containing, as an active ingredient, a compound that inhibits human STAT1; and a method for screening a candidate compound for an active ingredient of a systemic lupus erythematosus treatment agent including a step for selecting a compound that inhibits human STAT1.
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Inventors:
KISHIMOTO TADAMITSU (JP)
METWALLY HOZAIFA SAAD HASSAN (JP)
OZAWA TATSUHIKO (JP)
METWALLY HOZAIFA SAAD HASSAN (JP)
OZAWA TATSUHIKO (JP)
Application Number:
PCT/JP2023/022262
Publication Date:
December 21, 2023
Filing Date:
June 15, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
International Classes:
A61K45/00; A61P1/04; A61P17/02; A61P31/04; A61P37/02; A61P43/00; G01N33/15
Other References:
LEE SEUNG JUN; GHARBI AMAL; YOU JUENG SOO; HAN HEE DONG; KANG TAE HEUNG; HONG SEONG HWI; PARK WON SUN; JUNG IN DUK; PARK YEONG-MIN: "Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 73, 1 August 2019 (2019-08-01), NL , pages 482 - 490, XP085729471, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2019.05.051
TAEKYUN KIM: "Pheophorbide a suppresses toll-like receptor signaling via IKKβ/NFκB/TBK1/IRF3 to improve survival in septic mice", ABSTRACTS OF PAPERS. 256TH NATIONAL MEETING (2018), 1 August 2018 (2018-08-01), XP093118485, Retrieved from the Internet [retrieved on 20240111]
VON BÜLOW VERENA, DUBBEN SVENJA, ENGELHARDT GABRIELA, HEBEL SILKE, PLÜMÄKERS BIRGIT, HEINE HOLGER, RINK LOTHAR, HAASE HAJO: "Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 179, no. 6, 15 September 2007 (2007-09-15), US , pages 4180 - 4186, XP093118488, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.6.4180
HOZAIFA METWALLY, TOSHIO TANAKA, SONGLING LI, GYANU PARAJULI, SUJIN KANG, HAMZA HANIEH, SHIGERU HASHIMOTO, JAYA P CHALISE, YOHANNE: "Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production", SCIENCE SIGNALING, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 13, no. 624, 24 March 2020 (2020-03-24), US , pages eaay0574 - 16, XP009551582, ISSN: 1945-0877, DOI: 10.1126/scisignal.aay0574
TANAKA, JUNYA: "Discussion - from a study using JAK/STAT system - sedative hypnotic bromovalerylurea as the signaling pathway which can become the target of the septicemic treatment", SHOCK, vol. 29, no. 2, 1 January 2014 (2014-01-01), pages 40 - 46, XP009551717, ISSN: 0919-8156
TAEKYUN KIM: "Pheophorbide a suppresses toll-like receptor signaling via IKKβ/NFκB/TBK1/IRF3 to improve survival in septic mice", ABSTRACTS OF PAPERS. 256TH NATIONAL MEETING (2018), 1 August 2018 (2018-08-01), XP093118485, Retrieved from the Internet
VON BÜLOW VERENA, DUBBEN SVENJA, ENGELHARDT GABRIELA, HEBEL SILKE, PLÜMÄKERS BIRGIT, HEINE HOLGER, RINK LOTHAR, HAASE HAJO: "Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 179, no. 6, 15 September 2007 (2007-09-15), US , pages 4180 - 4186, XP093118488, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.6.4180
HOZAIFA METWALLY, TOSHIO TANAKA, SONGLING LI, GYANU PARAJULI, SUJIN KANG, HAMZA HANIEH, SHIGERU HASHIMOTO, JAYA P CHALISE, YOHANNE: "Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production", SCIENCE SIGNALING, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 13, no. 624, 24 March 2020 (2020-03-24), US , pages eaay0574 - 16, XP009551582, ISSN: 1945-0877, DOI: 10.1126/scisignal.aay0574
TANAKA, JUNYA: "Discussion - from a study using JAK/STAT system - sedative hypnotic bromovalerylurea as the signaling pathway which can become the target of the septicemic treatment", SHOCK, vol. 29, no. 2, 1 January 2014 (2014-01-01), pages 40 - 46, XP009551717, ISSN: 0919-8156
Attorney, Agent or Firm:
IWATANI Ryo (JP)
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