Title:
NOVEL IONIZABLE LIPID USED FOR NUCLEIC ACID DELIVERY AS WELL AS LNP COMPOSITION AND VACCINE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143601
Kind Code:
A1
Abstract:
Provided in the present invention are a novel cationic lipid, a lipid nanoparticle and a nucleic acid vaccine. In the present invention, a specific cationic lipid is selected for preparing a lipid nanoparticle mRNA vaccine, which is found to have better in-vitro stability and can stimulate a stronger immunoreaction compared with LNPs prepared from cationic lipids in the prior art.
Inventors:
WANG HAOMENG (CN)
YAN ZHIHONG (CN)
LI JIN (CN)
YUAN JINBO (CN)
SHI JIANMING (CN)
DENG JIE (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
ZHU TAO (CN)
YAN ZHIHONG (CN)
LI JIN (CN)
YUAN JINBO (CN)
SHI JIANMING (CN)
DENG JIE (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
ZHU TAO (CN)
Application Number:
PCT/CN2023/073791
Publication Date:
August 03, 2023
Filing Date:
January 30, 2023
Export Citation:
Assignee:
CANSINO BIOLOGICS INC (CN)
International Classes:
C07C219/06; A61K31/713; A61P31/04; A61P31/10; A61P31/12; A61P35/00; C07C215/14; C07C229/12; C07C233/36; C07C255/24
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Other References:
LI, LINXIAN ET AL.: "Combinatorial Synthesis and High-Throughput Screening of Alkyl Amines for Nonviral Gene Delivery", BIOCONJUGATE CHEMISTRY, vol. 24, no. 9, 5 August 2013 (2013-08-05), pages 1543 - 1551, XP055262549, ISSN: 1043-1802, DOI: 10.1021/bc400158w
WANG, MING ET AL.: "A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery", ACS SYNTHETIC BIOLOGY, vol. 1, no. 9, 25 May 2012 (2012-05-25), pages 403 - 407, XP008165065, ISSN: 2161-5063, DOI: 10.1021/sb300023h
WANG, MING ET AL.: "A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery", ACS SYNTHETIC BIOLOGY, vol. 1, no. 9, 25 May 2012 (2012-05-25), pages 403 - 407, XP008165065, ISSN: 2161-5063, DOI: 10.1021/sb300023h
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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