NOVEL IONIZABLE LIPID FOR NUCLEIC ACID DELIVERY, AND LNP COMPOSITION AND VACCINE THEREOF

Title:

NOVEL IONIZABLE LIPID FOR NUCLEIC ACID DELIVERY, AND LNP COMPOSITION AND VACCINE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/143600

Kind Code:

A1

Abstract:

The present invention provides a novel cationic lipid, a lipid nanoparticle, and a nucleic acid vaccine. According to the present invention, a specific cationic lipid is selected to prepare a lipid nanoparticle mRNA vaccine, and the lipid nanoparticle mRNA vaccine is found to have better in-vitro stability and immunogenicity as compared with the prior art.

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Inventors:

YAN ZHIHONG (CN)
WANG HAOMENG (CN)
LI JIN (CN)
YUAN JINBO (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
ZHU TAO (CN)

Application Number:

PCT/CN2023/073789

Publication Date:

August 03, 2023

Filing Date:

January 30, 2023

Export Citation:

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Assignee:

CANSINO BIOLOGICS INC (CN)

International Classes:

A61K8/14; C07C217/08; A61K9/50; A61K39/145; A61P31/00; A61P31/12; C07C215/14; C07C219/06; C07C233/36; C07C255/24

Domestic Patent References:

WO2021055835A1	2021-03-25
WO2021159040A2	2021-08-12
WO2021204175A1	2021-10-14

Foreign References:

CN114149337A	2022-03-08
CN114404584A	2022-04-29
CN110352071A	2019-10-18
US20180303925A1	2018-10-25
US20190274968A1	2019-09-12
CN113402405A	2021-09-17

Attorney, Agent or Firm:

BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)

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