Title:
NOVEL LIPID
Document Type and Number:
WIPO Patent Application WO/2015/005253
Kind Code:
A1
Abstract:
The compound represented in formula (Ia) is provided as a novel cationic lipid which forms lipid particles; also provided are a lipid particle containing said compound, a nucleic acid lipid particle containing said lipid particle, and a drug containing said nucleic acid lipid particle as the effective ingredient.
Inventors:
KOIZUMI MAKOTO (JP)
ONISHI YOSHIYUKI (JP)
NIWA TAKAKO (JP)
TAMURA MASAKAZU (JP)
KASUYA YUJI (JP)
ONISHI YOSHIYUKI (JP)
NIWA TAKAKO (JP)
TAMURA MASAKAZU (JP)
KASUYA YUJI (JP)
Application Number:
PCT/JP2014/068002
Publication Date:
January 15, 2015
Filing Date:
July 07, 2014
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07C219/16; A61K9/127; A61K31/7088; A61K31/713; A61K47/48; A61K48/00; A61P1/16; A61P7/06; A61P35/00; C07D211/22; C07D211/46; C12N15/113
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Other References:
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NATURE, vol. 411, 2001, pages 494 - 498
CLINICAL CHEMISTRY, vol. 48, 2002, pages 1647 - 1653
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"Comprehensive Organic Transformations", 1999, WILEY-VCH
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D.D. LASIC: "Chemistry of lipids and liposomes", 1993, ELSEVIER B.V., article "Liposomes: from physics to applications"
J. CONTROLLED RELEASE, vol. 112, 2006, pages 280 - 290
NUCLEIC ACID RESEARCH, vol. 25, no. 22, 1997, pages 4429 - 4443
KORMANN, M., NATURE BIOTECHNOLOGY, vol. 29, 2011, pages 154 - 157
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See also references of EP 3020701A4
SCIENCE, vol. 286, 1999, pages 950 - 952
NATURE, vol. 411, 2001, pages 494 - 498
CLINICAL CHEMISTRY, vol. 48, 2002, pages 1647 - 1653
JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 2010, pages 7887 - 7901
GENE THERAPY, vol. 6, 1999, pages 271 - 281
"Comprehensive Organic Transformations", 1999, WILEY-VCH
"Comprehensive Organic Synthesis", 1991, PERGAMON PRESS
"Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
D.D. LASIC: "Chemistry of lipids and liposomes", 1993, ELSEVIER B.V., article "Liposomes: from physics to applications"
J. CONTROLLED RELEASE, vol. 112, 2006, pages 280 - 290
NUCLEIC ACID RESEARCH, vol. 25, no. 22, 1997, pages 4429 - 4443
KORMANN, M., NATURE BIOTECHNOLOGY, vol. 29, 2011, pages 154 - 157
SAMBROOK, J.; FRITSCH, E.F.; MANIATIS, T.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
NATURE BIOTECHNOLOGY, vol. 26, 2008, pages 561 - 569
NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 172 - 176
J. ORG. CHEM., vol. 66, no. 22, 2001, pages 7487 - 7495
See also references of EP 3020701A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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