Title:
NOVEL METHOD OF PROTECTING ISCHEMIC CARDIOPATHY
Document Type and Number:
WIPO Patent Application WO/2006/035673
Kind Code:
A1
Abstract:
A method of preventing necrosis in myocardial cells occurring ischemia caused by blood flow injury or postischemic reperfusion; and a method of evaluating the necrosis in vitro and/or in vivo. A pharmaceutical composition for inhibiting cell death in ventricle muscle; a pharmaceutical composition for protecting cardiac muscle in a cardiac surgery and a transplant surgery; and a pharmaceutical composition for preventing a disease caused by necrosis.
Inventors:
OKADA YASUNOBU
URAMOTO HIROMI
URAMOTO HIROMI
Application Number:
PCT/JP2005/017494
Publication Date:
April 06, 2006
Filing Date:
September 22, 2005
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
NAT INST NATURAL SCIENCES (JP)
OKADA YASUNOBU
URAMOTO HIROMI
NAT INST NATURAL SCIENCES (JP)
OKADA YASUNOBU
URAMOTO HIROMI
International Classes:
A61K45/00; A61G13/00; A61K31/23; A61K31/4545; A61K31/7076; A61P9/00; A61P9/10; A61P43/00; G01N33/15
Domestic Patent References:
| WO1987006836A1 | 1987-11-19 | |||
| WO2001016137A1 | 2001-03-08 |
Foreign References:
| EP1449539A2 | 2004-08-25 | |||
| EP1240906A1 | 2002-09-18 |
Other References:
DE TASSIGNY A. ET AL: "Hypo-osmotic stress inhibits doxorubicin-induced apoptosis via a protein kinase A-dependent mechanism in cardiomyocytes", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 31, no. 7, July 2004 (2004-07-01), pages 438 - 443, XP002993772
JUNG Y.-S. ET AL: "Essential role of PKC-epsilon in the oritective effect of high glucose against hypoxic injury in cardiac myoblast", FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), pages A84
YAO Z. ET AL: "Signal transduction of flumazenil-induced preconditioning in myocytes", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 280, no. 3 PT 2, 2001, pages H1249 - H1255, XP002993773
ENDOH M.: "Changes in intracellular Ca2+ mobilization and Ca2+ sensitization as mechanisms of action of physiological interventions and inotropic agents in intact myocardial cells", JPN HEART J., vol. 39, no. 1, 1998, pages 1 - 44, XP002993774
SANADA S. ET AL: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase", CIRCULATION, vol. 104, no. 6, 2001, pages 705 - 710, XP002993775
RAFIEE P. ET AL: "Activation of protein kinase in chronically hypoxic infant and rabbit haerts: role in cardioprotection", CIRCULATION, vol. 106, no. 2, 2002, pages 239 - 245, XP002993776
MOLLHOFF T. ET AL: "Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin", EUR J ANAESTHESIOL, vol. 19, no. 11, 2002, pages 796 - 802, XP002993777
YOSHIOKA Y. ET AL: "Coactivation of protein kinase A and protein kinase C prevents H2O2-induced necrosis through ERK and p38 MAP kinase activation in PC12 cells", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 94, no. 1, 2004, pages 134P, XP002993778
CHEN M. ET AL: "Resistance to hydrogen peroxide induced injury in cardiomyocytes from PARP-1 deficient mice", FASEB JOURNAL, vol. 18, no. 5 P.AB, April 2004 (2004-04-01), pages 790 - 795, XP002993779
GREEN P.S. ET AL: "Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis", BIOCHIM BIOPHYS ACTA, vol. 1588, no. 1, 2002, pages 94 - 101, XP004388050, DOI: doi:10.1016/S0925-4439(02)00144-8
COLLIER M.L. ET AL: "Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes", CIRC RES, vol. 76, no. 2, 1995, pages 317 - 324, XP002993780
DUAN D. ET AL: "Loss of Early and Late Cardiac Ischemic Preconditioning in Cystic Fibrosis Transmembrane Conductance Regulator Deficient Mice", FASEB JOURNAL, vol. 18, no. 4-5, 2004, pages 429.6, XP002993781
CHEN H. ET AL: "Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart", CIRCULATION, vol. 110, no. 6, August 2004 (2004-08-01), pages 700 - 704, XP002993782
KELLEY T.J. ET AL: "CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells", AM J RESPIR CELL MOL BIOL, vol. 13, no. 6, 1995, pages 657 - 664, XP002993783
JUNG Y.-S. ET AL: "Essential role of PKC-epsilon in the oritective effect of high glucose against hypoxic injury in cardiac myoblast", FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), pages A84
YAO Z. ET AL: "Signal transduction of flumazenil-induced preconditioning in myocytes", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 280, no. 3 PT 2, 2001, pages H1249 - H1255, XP002993773
ENDOH M.: "Changes in intracellular Ca2+ mobilization and Ca2+ sensitization as mechanisms of action of physiological interventions and inotropic agents in intact myocardial cells", JPN HEART J., vol. 39, no. 1, 1998, pages 1 - 44, XP002993774
SANADA S. ET AL: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase", CIRCULATION, vol. 104, no. 6, 2001, pages 705 - 710, XP002993775
RAFIEE P. ET AL: "Activation of protein kinase in chronically hypoxic infant and rabbit haerts: role in cardioprotection", CIRCULATION, vol. 106, no. 2, 2002, pages 239 - 245, XP002993776
MOLLHOFF T. ET AL: "Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin", EUR J ANAESTHESIOL, vol. 19, no. 11, 2002, pages 796 - 802, XP002993777
YOSHIOKA Y. ET AL: "Coactivation of protein kinase A and protein kinase C prevents H2O2-induced necrosis through ERK and p38 MAP kinase activation in PC12 cells", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 94, no. 1, 2004, pages 134P, XP002993778
CHEN M. ET AL: "Resistance to hydrogen peroxide induced injury in cardiomyocytes from PARP-1 deficient mice", FASEB JOURNAL, vol. 18, no. 5 P.AB, April 2004 (2004-04-01), pages 790 - 795, XP002993779
GREEN P.S. ET AL: "Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis", BIOCHIM BIOPHYS ACTA, vol. 1588, no. 1, 2002, pages 94 - 101, XP004388050, DOI: doi:10.1016/S0925-4439(02)00144-8
COLLIER M.L. ET AL: "Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes", CIRC RES, vol. 76, no. 2, 1995, pages 317 - 324, XP002993780
DUAN D. ET AL: "Loss of Early and Late Cardiac Ischemic Preconditioning in Cystic Fibrosis Transmembrane Conductance Regulator Deficient Mice", FASEB JOURNAL, vol. 18, no. 4-5, 2004, pages 429.6, XP002993781
CHEN H. ET AL: "Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart", CIRCULATION, vol. 110, no. 6, August 2004 (2004-08-01), pages 700 - 704, XP002993782
KELLEY T.J. ET AL: "CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells", AM J RESPIR CELL MOL BIOL, vol. 13, no. 6, 1995, pages 657 - 664, XP002993783
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (2-6 Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka 41, JP)
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