Title:
NOVEL NLRP3 INFLAMMASOME INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2024/041460
Kind Code:
A1
Abstract:
The present invention provides compounds of Formula (I) : wherein all of the variables are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of disease and disorders mediated by NLRP3.
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Inventors:
LIANG CONGXIN (CN)
LI SHUANGJIANG (CN)
TANG WEI (CN)
TANG XIAOJING (CN)
LI SHUANGJIANG (CN)
TANG WEI (CN)
TANG XIAOJING (CN)
Application Number:
PCT/CN2023/113812
Publication Date:
February 29, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
HANGZHOU HIGHLIGHTLL PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/53; A61P1/16; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/10; A61P19/02; A61P19/06; A61P25/00; A61P25/16; A61P29/00; A61P35/00; A61P35/02; C07C43/20; C07C221/00; C07C223/02; C07C231/02; C07D233/90
Domestic Patent References:
| WO2023088856A1 | 2023-05-25 |
Foreign References:
| CN105481687A | 2016-04-13 | |||
| CN1313280A | 2001-09-19 | |||
| CN105593221A | 2016-05-18 | |||
| CN102206152A | 2011-10-05 | |||
| CN113784957A | 2021-12-10 | |||
| CN1735615A | 2006-02-15 |
Other References:
DATABASE REGISTRY 6 May 2015 (2015-05-06), ANONYMOUS : "Benzene, 2-methoxy-4- methyl-1-(trimethox ymethyl)- (CA INDEX NAME)", XP093144639, retrieved from STN Database accession no. 1699710-63-8
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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