NOVEL PEPTIDE-CONJUGATED OLIGOMERIC COMPOUNDS

Title:

NOVEL PEPTIDE-CONJUGATED OLIGOMERIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2004016274

Kind Code:

B1

Abstract:

The present invention relates to novel amphipathic peptide-conjugated oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compounds comprising conjugating the compounds to amphipathic moieties such as amphipathic peptides.

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Inventors:

MANOHARAN MUTHIAH (US)
MAIER MARTIN A (US)

Application Number:

PCT/US2003/025567

Publication Date:

May 27, 2004

Filing Date:

August 15, 2003

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Assignee:

ISIS PHARMACEUTICALS INC (US)
MANOHARAN MUTHIAH (US)
MAIER MARTIN A (US)

International Classes:

C07K9/00; C07K14/00; C12N15/113; (IPC1-7): A61K31/7088; A61K38/08; A61K38/10; A61K39/44; C07H21/00

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